ER-000444793
- CAS No.
- 792957-74-5
- Chemical Name:
- ER-000444793
- Synonyms
- ER-000444793;ER-000444793 (ER000444793);N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793
- CBNumber:
- CB23155149
- Molecular Formula:
- C23H18N2O2
- Molecular Weight:
- 354.4
- MDL Number:
- MFCD31544321
- MOL File:
- 792957-74-5.mol
ER-000444793 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7582 | ER-000444793 >98.0% | 792957-74-5 | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-7582 | ER-000444793 >98.0% | 792957-74-5 | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-7582 | ER-000444793 >98.0% | 792957-74-5 | 10mg | $660 | 2021-12-16 | Buy |
| ChemScene | CS-7582 | ER-000444793 >98.0% | 792957-74-5 | 50mg | $2340 | 2021-12-16 | Buy |
| ChemScene | CS-7582 | ER-000444793 >98.0% | 792957-74-5 | 100mg | $3540 | 2021-12-16 | Buy |
ER-000444793 Chemical Properties,Uses,Production
Biological Activity
ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. It inhibits mPTP with IC50 of 2.8 μM.
in vitro
ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. It potently and dose-dependently inhibits Ca 2+ -induced mPT. It binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled -CsA from rhCypD protein. Together, these data suggest the mechanism of it in delaying mPT is independent of CypD functional inhibition.
target
IC50: 2.8 μM (mPTP)
ER-000444793 Preparation Products And Raw materials
Raw materials
Preparation Products
ER-000444793 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |