fluclorolone acetonide
- CAS No.
- 3693-39-8
- Chemical Name:
- fluclorolone acetonide
- Synonyms
- Topilar;RS-2252;Flulorolone;Fluclorolone;Flucloronide;Flucortolone acetonide;Flucloronide (Fluclorolone Acetonide);9α,11β-Dichloro-6α-fluoro-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;9,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione;9α,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17α-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione
- CBNumber:
- CB3900941
- Molecular Formula:
- C24H29Cl2FO5
- Molecular Weight:
- 487.392
- MDL Number:
- MFCD00200362
- MOL File:
- 3693-39-8.mol
- MSDS File:
- SDS
| Boiling point | 598.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| pka | 12.87±0.10(Predicted) |
| FDA UNII | MG258KTA37 |
| ATC code | D07AC02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373-H361-H362 |
| Precautionary statements | P260-P314-P501-P201-P202-P281-P308+P313-P405-P501-P201-P260-P263-P264-P270-P308+P313 |
fluclorolone acetonide price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F418900 | Flucloronide | 3693-39-8 | 2.5mg | $165 | 2021-12-16 | Buy |
| TRC | F418900 | Flucloronide | 3693-39-8 | 25mg | $1320 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0016509 | FLUCLORONIDE 95.00% | 3693-39-8 | 5MG | $495.19 | 2021-12-16 | Buy |
fluclorolone acetonide Chemical Properties,Uses,Production
Originator
Topilar,Syntex,UK,1971
Uses
fluclorolone acetonide is a synthetic glucocorticoid with anti-inflammatory properties. Studies suggest that it is a potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis.
Definition
ChEBI: Fluclorolone acetonide is a 21-hydroxy steroid.
Manufacturing Process
To 6α-fluoro-16α-hydroxy-hydrocortisone 21-acetate, described by Mills et al,
J. Am. Chem. Soc., volume 81, pages 1264 to 1265, March 5, 1959, there
was added acetic anhydride in dry pyridine. The reaction mixture was left at
room temperature overnight and was then poured with stirring into ice water.
The resulting precipitate was filtered, washed with water and crystallized from
acetone-hexane to give 6α-fluoro-16α-hydroxy-hydrocortisone-16α,21-
diacetate. This was reacted with methane-sulfonyl chloride in dimethyl
formamide in the presence of pyridine at 80°C for 1 hour. The mixture was
cooled, diluted with water and extracted with ethyl acetate. The extract was
washed with water, dried over anhydrous sodium sulfate and the ethyl acetate
was evaporated. By recrystallization of the residue from acetone-hexane there
was obtained 6α-fluoro-Δ4,9(11)-pregnadiene-16α,17α,21-triol-3,20-dione-
16α,21-diacetate.
This was reacted with chlorine to give the dichloropregnene compound, then
with selenium dioxide to give the dichloropregnadiene compound. By
hydrolysis with methanolic potassium hydroxide there was obtained the free
6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione. By
treatment with acetone in the presence of perchloric acid, the 16,17-acetonide
of 6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione
was formed.
Therapeutic Function
Glucocorticoid
fluclorolone acetonide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
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