Guanoxan
- CAS No.
- 2165-19-7
- Chemical Name:
- Guanoxan
- Synonyms
- Guanoxan;Guanoxane;Guanoxan USP/EP/BP;2-(GuanidinoMethyl)-1,4-benzodioxan;(1,4-Benzodioxan-2-ylmethyl)guanidine;2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)guanidine;1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)guanidine;N-[(2,3-Dihydro-1,4-benzodioxin-2-yl)Methyl]guanidine;Guanidine, N-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-
- CBNumber:
- CB41117509
- Molecular Formula:
- C10H13N3O2
- Molecular Weight:
- 207.23
- MDL Number:
- MOL File:
- 2165-19-7.mol
| Melting point | 164-165° |
|---|---|
| Boiling point | 339.3±45.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| pka | pKa 12.3 (Uncertain) |
| FDA UNII | 9V0MRL0R5Y |
| ATC code | C02CC03 |
Guanoxan price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0011596 | GUANOXAN 95.00% | 2165-19-7 | 5MG | $385 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 58482 | Guanoxan | 2165-19-7 | 10mg | $650 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0011596 | GUANOXAN 95.00% | 2165-19-7 | 10MG | $750.75 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0011596 | GUANOXAN 95.00% | 2165-19-7 | 100MG | $1963.5 | 2021-12-16 | Buy |
Guanoxan Chemical Properties,Uses,Production
Originator
Envacar,Pfizer
Uses
Guanoxan is a sympatholytic drug related to Guanethidine (G815000). Guanoxan is used in the treatment of hypertension.
Definition
ChEBI: Guanoxan is a benzodioxine.
Manufacturing Process
2 Methods of producing of 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine:
1. 3.3 parts by weight of 2-aminomethyl-1,4-benzodioxane and 2.78 parts by
weight of S-methylisothiouronium sulfate were dissolved in 20 parts by
volume of water, and the resulting aqueous solution was heated under reflux
for 3 h. At the end of this time, the solvent was removed by means of
evaporation under reduced pressure and the residue so obtained dissolved in
a minimum amount of fresh water and treated with charcoal. Upon filtration,
there was obtained a clear filtrate which, on standing, soon afforded pure
crystals of di(2-guanidinomethyl-1,4-benzodioxane)sulfate, melting point
204°-205°C.
The base 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine may be obtained
by reaction of di(2-guanidinomethyl-1,4-benzodioxane)sulfate with, for
example, sodium hydroxide.
2. o-Dihydroxybenzene reacted with epichlorhydrine in the presence sodium
hydroxide and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine was obtained.
To solution of 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine thionylchloride
was added to give 2-chlormethyl-2,3-dihydro-1,4-benzodioxine.
2-Chloromethyl-2,3-dihydro-1,4-benzodioxine reacted with benzylamine to
produced 2-benzylaminomethyl-2,3-dihydro-1,4-benzodioxine, which was
reduced at the presence of hydrogen and Pd-C (catalyst) to 2-aminomethyl-
2,3-dihydro-1,4-benzodioxine.
2-Aminomethyl-2,3-dihydro-1,4-benzodioxine was treated by Smethylisothiouronium sulfate and there was produced 2-guanidinemethyl-2,3-
dihydro-1,4-benzodioxine.
brand name
Envacar (Pfizer).
Therapeutic Function
Antihypertensive
Guanoxan Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17997 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
