IBUFENAC
- CAS No.
- 1553-60-2
- Chemical Name:
- IBUFENAC
- Synonyms
- 2-(4-Isobutylphenyl)acetic acid;ibunac;medirex;isodilan;ibufenac;dytransin;NSC 99976;2-(4-Isobutylphenyl);p-isobutyl-alpha-toluicacid;(p-isobutylphenyl)aceticacid
- CBNumber:
- CB4506742
- Molecular Formula:
- C12H16O2
- Molecular Weight:
- 192.25
- MDL Number:
- MFCD00864374
- MOL File:
- 1553-60-2.mol
| Melting point | 85-87°C |
|---|---|
| Boiling point | 288.25°C (rough estimate) |
| Density | 1.0240 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.36±0.10(Predicted) |
| color | White to Off-White |
| FDA UNII | 5V4WIX44VI |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2916399090 | |||||||||
| Toxicity | LD50 orally in mice: 1.8 g/kg (Adams) | |||||||||
| NFPA 704 |
|
IBUFENAC price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17874 | Ibufenac ≥95% | 1553-60-2 | 10mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17874 | Ibufenac ≥95% | 1553-60-2 | 25mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 17874 | Ibufenac ≥95% | 1553-60-2 | 50mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 17874 | Ibufenac ≥95% | 1553-60-2 | 100mg | $310 | 2024-03-01 | Buy |
| TRC | I130000 | Ibufenac | 1553-60-2 | 250mg | $795 | 2021-12-16 | Buy |
IBUFENAC Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Used as an analgesic, anti-inflammatory.
Definition
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 4-isobutylphenyl group. Although it was shown to be effective in treatment of rheumatoid arthritis, the clinical use of ibufenac was discontinued due to hepatot xic side-effects.
Biological Activity
ibufenac is a dual cox-1 and -2 inhibitor.cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs), is an enzyme that is responsible for formation of prostanoids, such as thromboxane and prostaglandins.
in vitro
ibufenac was identified as an analog of the nsaid ibuprofen that could inhibit cox-1 and -2 activity with ic50 values of 17.4 and 13.1 μm, respectively [1].
in vivo
in a previous animal study, two new structural analogs, r3 and r4, along with their parent compounds, ibufenac and ibuprofen, were evaluated for their biopharmaceutical properties. aanti-inflammatory activity was evaluated by topically administering drugs to inhibit inflammation induced by using either clove oil or arachidonic acid. results showed that the rank order of activity was ibufenac approximately equal to ibuprofen > r3 approximately equal to r4 [2].
IC 50
17.4 and 13.1 μm for cox-1 and -2, respectively.
References
[1] gülcan, h. o.,nlü, s.,dimoglo, a., et al. marginally designed new profen analogues have the potential to inhibit cyclooxygenase enzymes. arch.pharm.chem.life sci. 348, 55-61 (2015).
[2] rao cs, schoenwald rd, barfknecht cf, laban sl. biopharmaceutical evaluation of ibufenac, ibuprofen, and their hydroxyethoxy analogs in the rabbit eye. j pharmacokinet biopharm. 1992 aug;20(4):357-88.
[3] t. m. chalmers.
IBUFENAC Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| WinWin Chemical CO., Limited | +86-0577-64498589 +8615325081899 | sales@win-winchemical.com | China | 14145 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9330 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4226 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from IBUFENAC manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | IBUFENAC
1553-60-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | IBUFENAC
1553-60-2
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |