TRIMETHOBENZAMIDE HYDROCHLORIDE
- CAS No.
- 554-92-7
- Chemical Name:
- TRIMETHOBENZAMIDE HYDROCHLORIDE
- Synonyms
- tigan;Trimethobenzamide HCL;ro2-9578;Tribenzagan HCl;tiganhydrochloride;LABOTEST-BB LT00772325;Tribenzagan Hydrochloride;TRIMETHOBENZAMIDE HYDROCHLORIDE;Trimethobenzamide HCl (Ro 2-9578);TRIMETHOBENZAMIDEHYDROCHLORIDE,USP
- CBNumber:
- CB4712200
- Molecular Formula:
- C21H29ClN2O5
- Molecular Weight:
- 424.92
- MDL Number:
- MFCD00057999
- MOL File:
- 554-92-7.mol
| Melting point | 187.5-190° |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | WDQ5P1SX7Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H334 | |||||||||
| Precautionary statements | P261-P280-P284-P301+P312+P330-P304+P340-P342+P311 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2924296000 | |||||||||
| NFPA 704 |
|
TRIMETHOBENZAMIDE HYDROCHLORIDE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1692006 | Trimethobenzamide hydrochloride | 554-92-7 | 200mg | $491 | 2024-03-01 | Buy |
| TCI Chemical | T3525 | Trimethobenzamide Hydrochloride >98.0%(HPLC)(T) | 554-92-7 | 1g | $118 | 2024-03-01 | Buy |
| TCI Chemical | T3525 | Trimethobenzamide Hydrochloride >98.0%(HPLC)(T) | 554-92-7 | 5g | $352 | 2024-03-01 | Buy |
| Cayman Chemical | 24145 | Trimethobenzamide (hydrochloride) ≥95% | 554-92-7 | 50mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 24145 | Trimethobenzamide (hydrochloride) ≥95% | 554-92-7 | 100mg | $111 | 2024-03-01 | Buy |
TRIMETHOBENZAMIDE HYDROCHLORIDE Chemical Properties,Uses,Production
Originator
Tigan,Beecham,US,1973
Uses
antiemetic
Uses
Trimethobenzamide Hydrochloride a pharmaceutical compound used in the prevention of nausea and vomiting in patients. Also used in the treatment of Parkinson’s disease.
Manufacturing Process
To 122 grams (1 mol) of p-hydroxybenzaldehyde in 1 liter of chlorobenzene
were added 66 grams (1.04 mols) of sodium methoxide (85%) and 108 grams
(1 mol) of 2-dimethylaminoethyl chloride. The mixture was stirred and
refluxed for 15 hours, then cooled and the precipitated sodium chloride
filtered off. The filtrate was concentrated at steam temperature under water
vacuum and the residual oil was fractionated in high vacuum, to give 4-(2-
dimethylaminoethoxy)benzaldehyde, BP2.2145°C.
Two teaspoons of Raney nickel catalyst were added to a solution of 65.6
grams (0.34 mol) of 4-(2-dimethylaminoethoxy)benzaldehyde in 300 ml of
10% ammoniacal ethanol. The mixture was hydrogenated at 80°C and a
pressure of 1,000 psi. The catalyst was filtered off, the volatiles were distilled
off and the residual oil was fractionated in high vacuum, to obtain 4-(2-
dimethylaminoethoxy)benzylamine, BP0.3120° to 123°C.
To 9.7 grams (0.05 mol) of 4-(2-dimethylaminoethoxy)benzylamine, dissolved
in 100 ml of acetonitrile, was added all at once 12 grams (0.051 mol) of
3,4,5-trimethoxybenzoyl chloride, dissolved in 75 ml of acetonitrile. The
mixture was stirred and refluxed for 8 hours, and then cooled. The crystalline
solid, which had formed, was filtered off, washed with acetonitrile and
recrystallized from acetonitrile, to give 4-(2-dimethylaminoethoxy)-N-(3,4,5-
trimethoxybenzoyl)benzylamine hydrochloride, MP 185° to 186°C.
brand name
Tigan (King).
Therapeutic Function
Antinauseant
TRIMETHOBENZAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 2929 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9823 | 79 |
View Lastest Price from TRIMETHOBENZAMIDE HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | TriMethobenzaMide Hydrochloride
554-92-7
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd |
-
- TriMethobenzaMide Hydrochloride
554-92-7
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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