Cyclen
- CAS No.
- 294-90-6
- Chemical Name:
- Cyclen
- Synonyms
- 1,4,7,10-TETRAAZACYCLODODECANE;1,4,7,10-Tetrazacyclododecane;Gm-D;CYCLEN;NSC 629374;Cyclen,97%;Cyclen(M-100);Cyclen, >=99%;Kryptofix 11 aza;Cyclen≥ 99% (GC)
- CBNumber:
- CB5158782
- Molecular Formula:
- C8H20N4
- Molecular Weight:
- 172.27
- MDL Number:
- MFCD00066281
- MOL File:
- 294-90-6.mol
- MSDS File:
- SDS
| Melting point | 110-113 °C (lit.) |
|---|---|
| Boiling point | 292.61°C (rough estimate) |
| Density | 1.0415 (rough estimate) |
| vapor pressure | 0.004Pa at 20℃ |
| refractive index | 1.5872 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.53±0.20(Predicted) |
| form | Crystalline Powder |
| color | Almost white to slightly yellow |
| Water Solubility | almost transparency |
| BRN | 606114 |
| Stability | hygroscopic |
| InChIKey | QBPPRVHXOZRESW-UHFFFAOYSA-N |
| LogP | -0.63 at 20℃ |
| CAS DataBase Reference | 294-90-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 964584YO2O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H314-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/38-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XA5253000 | |||||||||
| F | 3-9-34 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Cyclen price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 339652 | Cyclen 97% | 294-90-6 | 250mg | $224 | 2024-03-01 | Buy |
| TCI Chemical | T1874 | 1,4,7,10-Tetraazacyclododecane >97.0%(GC)(T) | 294-90-6 | 1g | $28 | 2024-03-01 | Buy |
| TCI Chemical | T1874 | 1,4,7,10-Tetraazacyclododecane >97.0%(GC)(T) | 294-90-6 | 5g | $83 | 2024-03-01 | Buy |
| Strem Chemicals | 07-1941 | 1,4,7,10-Tetraazacyclododecane, min. 98% CYCLEN | 294-90-6 | 1g | $69 | 2024-03-01 | Buy |
| Strem Chemicals | 07-1941 | 1,4,7,10-Tetraazacyclododecane, min. 98% CYCLEN | 294-90-6 | 5g | $209 | 2024-03-01 | Buy |
Cyclen Chemical Properties,Uses,Production
Chemical Properties
almost white to slightly yellow crystalline powder, soluble in methanol, ethanol, dmso and other organic solvents, derived from stephania cepharantha.
Uses
Cyclen is an azamocrocycle, which can be used in the development of fluorescent nanosensors for the detection of metal ions.
Application
Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imaging) agents.
Definition
ChEBI: 1,4,7,10-tetraazacyclododecane is an azacycloalkane that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogen atoms. It is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane.
Synthesis Reference(s)
Journal of the American Chemical Society, 96, p. 2268, 1974 DOI: 10.1021/ja00814a056
General Description
Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.
Flammability and Explosibility
Not classified
Synthesis
Some syntheses exploit the Thorpe-Ingold effect to facilitate ring-formation. Illustrative is the reaction of the deprotonated tosylamides with ditosylates:
TsN(CH2CH2NTsNa)2 + TsN(CH2CH2OTs)2 → (TsNCH2CH2)4
The resulting macrocycle can be deprotected with strong acid. Base gives the tetramine.
High dilution conditions result in a low reaction rate penalty and this disadvantage is removed in an alternative procedure starting from triethylenetetraamine and dithiooxamide to a bisamidine – also a bis(imidazoline) – followed by reduction and ring expansion with DIBAL. 
In one study cyclen is covalently bonded through a propylene molecular spacer to adenine and chelated with zinc diperchlorate. This complex is able to selectively bind uracil and uridine in a 1:2 ratio both through the adenine part and cyclen part of the molecule as evidenced by mass spectrometry.
wiki/Cyclen
Cyclen Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +8618917565227 | prisun@prisunpharma.com | China | 215 | 58 |
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 | sales001@rokechem.com | China | 255 | 58 |
| Changzhou Zechong Biopharma Co., Ltd. | +undefined18621330623 | sales@zechongchem.com | China | 28 | 58 |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | trade.kilopharma@foxmail.com | China | 27 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18232 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
View Lastest Price from Cyclen manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-17 | Cyclen
294-90-6
|
US $30.00 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-05-17 | Cyclen
294-90-6
|
US $0.00 / Kg/Drum | 1KG | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-04-08 | Cyclen
294-90-6
|
US $8.00-0.80 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |