Cyclen

Cyclen Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

almost white to slightly yellow crystalline powder, soluble in methanol, ethanol, dmso and other organic solvents, derived from stephania cepharantha.

Verwenden

Cyclen is an azamocrocycle, which can be used in the development of fluorescent nanosensors for the detection of metal ions.

Application

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imaging) agents.

Allgemeine Beschreibung

Cyclen is a microcyclic tetramine that can be used as a ligand that forms a co-ordination linkage with the surface metal cations. It can be used as a synthetic precursor. It can be prepared by S-alkylation of dithiooxamide with an excess amount of bromoethane.

Synthese

Some syntheses exploit the Thorpe-Ingold effect to facilitate ring-formation. Illustrative is the reaction of the deprotonated tosylamides with ditosylates:
TsN(CH2CH2NTsNa)2 + TsN(CH2CH2OTs)2 → (TsNCH2CH2)4
The resulting macrocycle can be deprotected with strong acid. Base gives the tetramine.
High dilution conditions result in a low reaction rate penalty and this disadvantage is removed in an alternative procedure starting from triethylenetetraamine and dithiooxamide to a bisamidine – also a bis(imidazoline) – followed by reduction and ring expansion with DIBAL.

In one study cyclen is covalently bonded through a propylene molecular spacer to adenine and chelated with zinc diperchlorate. This complex is able to selectively bind uracil and uridine in a 1:2 ratio both through the adenine part and cyclen part of the molecule as evidenced by mass spectrometry.
wiki/Cyclen

Cyclen Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Cyclen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2966	58
AFINE CHEMICALS LIMITED	0571-85134551 18958018566;	info@afinechem.com	China	15377	58
PRISUN PHARMATECH CO.,LTD	+86-021-54326183-8001 +8618917565227	prisun@prisunpharma.com	China	215	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Changzhou Zechong Biopharma Co., Ltd.	+undefined18621330623	sales@zechongchem.com	China	28	58
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd	+86-02223869539 +86-15560057295	trade.kilopharma@foxmail.com	China	27	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3000	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18219	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	952	58

294-90-6()Verwandte Suche:

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• Cyclen,97%
• Kryptofix 11 aza
• 10-Tetraazacyclododecane
• Cyclen(M-100)
• Tetraaza-12-Crown-4 ( CYclen)
• Tetraazacyclododecane (Cyclen)
• Cyclen, 97% 250MG
• NSC 629374
• Cyclen,1,4,7,10-Tetrazacyclododecane
• Cyclen ( 1,4,7,10-Tetraaza Cyclododecane)
• 1,4,7,10-TETRAAZACYCLODODECANE, 98.5%
• 1,4,7,10-TETRAAZACYCLODODECANEHCL
• 1,4,7,10-Tetraazacyclododecane( Cyclenine )
• 1,4,7,10-Tetraazacyclododecane,98% CYCLEN
• Cyclen, >=99%
• Cyclen≥ 99% (GC)
• 1,4,7,10-Tetraazacyclododecane, min. 98%
• CYCLEN
• 1,4,7,10-Tetracyclododecane
• 1,4,7,1-Tetraazacyclododecane
• 1,4,7,10-Tetraazacyclododecane,min.98%CYCLEN
• 1,4,7,10-TETRAAZACYCLODODECANE(CYCLEN)
• 1,4,7,10-Tetraazacyclododecane 98%
• Tetraaza 12-crown-4
• 1,4,7,10-tetrazacyclododecane {Cyclene)
• Gm-D
• Gadobutrol Impurity 46
• Gadobutrol Impurity 68
• 1,4,7,10-tetraazacyc
• Gadobutrol Impurity 39
• CYCLEN wheel ring vine Ning
• 1,4,7,10-TETRAAZACYCLODODECANE
• 1,4,7,10-Tetrazacyclododecane
• Ring rattan, ning
• Gadobutrol Impurity 12 4HCl
• POTASSIUM SULFITE 10117-38-1
• 1,4,7,10-Tetraazacyclododecane (6CI, 8CI, 9CI, ACI)
• Gadobutrol Impurity 39 (Cyclen)
• 10-[(1SR,2RS)-2,3-dihydroxy-1- hydroxymethylpropyl]-1,4,7,10- tetraazacyclododecane-1,4,7-triacetic acid
• Gadolinium Butanol Impurity 27
• Gadolinium Butanol Impurity 39
• 294-90-6
• C8H20N4
• C8H24N4
• Chelation/Complexation Compounds
• Macrocycles for Host-Guest Chemistry
• Crown Ethers
• Synthetic Reagents
• Achiral Nitrogen
• Cy-N
• Other APIs
• API
• Crown Ethers
• Functional Materials
• organic amine
• Heterocycles
• Intermediates & Fine Chemicals
• Pharmaceuticals