5-Benzylidenehydantoin
- CAS No.
- 3775-01-7
- Chemical Name:
- 5-Benzylidenehydantoin
- Synonyms
- RARECHEM AP KH 0029;TIMTEC-BB SBB007867;Benzylidene hydantoin;5-Benzylidendhydantoin;5-BENZYLIDENEHYDANTOIN;5-phenylmethylenehydantoin;5-Benzylideneimidazolidine-2,4-dione;5-Benzylidene-2,4-imidazolidinedione;(5E)-5-Benzylidene-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-(phenylmethylene)-
- CBNumber:
- CB5179770
- Molecular Formula:
- C10H8N2O2
- Molecular Weight:
- 188.18
- MDL Number:
- MFCD00014494
- MOL File:
- 3775-01-7.mol
5-Benzylidenehydantoin price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth Carbosynth | FB149856 | 5-Benzylidenehydantoin | 3775-01-7 | 25g | $95 | 2021-12-16 | Buy |
| Matrix Scientific | 172046 | 5-Benzylidenehydantoin | 3775-01-7 | 5g | $118 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB149856 | 5-Benzylidenehydantoin | 3775-01-7 | 50g | $166 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB149856 | 5-Benzylidenehydantoin | 3775-01-7 | 100g | $288 | 2021-12-16 | Buy |
| Matrix Scientific | 172046 | 5-Benzylidenehydantoin | 3775-01-7 | 25g | $370 | 2021-12-16 | Buy |
5-Benzylidenehydantoin Chemical Properties,Uses,Production
Description
Derivatives of 5-Benzylidenehydantoin are well known of their various attractive bioactivities such as anticancer, antimicrobial, antidiabetic and tyrosinase inhibitor. UPR1024 belongs to a new class of EGFR inhibitors characterized by a hydantoin nucleus and a 5-benzylidene substituent having a double bond conjugated with a carbonyl group on the hydantoin ring. The compound had antiproliferative and proapoptotic effects when tested on the non-small cell lung cancer cell line A549[1-2].
Biological Activity
5-Benzylidenehydantoins inhibited the EGFR kinase and exhibited an antiproliferative action on A431 human epidermoid carcinoma cells. The conjugated exo-cyclic double bond at the C5 position appeared essential for both EGFR and cell growth inhibition, indicating that the 5-benzylidene hydantoin core would be a suitable scaffold for generating new antiproliferative compounds[3].
References
[1] Haq, K. U. et al. “Synthesis of 5-benzylidene-hydantoin and 5-benzylidene-creatinine derivatives under mixed catalyst systems of urea-p-toluenesulfonic acid (Urea-PTSA) and guanidine hydrochloride-triethylamine (GnHCl-TEA).”(2020).
[2] Andrea Cavazzoni. “Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines.” Molecular Cancer Therapeutics 7 2 (2008): 361–70.
5-Benzylidenehydantoin Preparation Products And Raw materials
Raw materials
Preparation Products
5-Benzylidenehydantoin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Donghua Jinlong Chemical Co., LTD | +86-031166619888 +86-19333738986 | donghuajinlong@glycine.com.cn | China | 18 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9340 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 1829 | 58 |
| Kindchem(Nanjing)Co.,Ltd | +86-025-025-85281586 +8618651653755 | sales@kindchem.cn | China | 1227 | 58 |
| SHIJIAZHUANG DONGHUA JINLONG CHEMICAL CO.,LTD. | 0311-66619688 15632114516 | donghuajinlong@glycine.com.cn | China | 11 | 58 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 8465 | 55 |
| Beijing Hihealth Pharma. Sci. & Tech. Co.,Ltd. | 13911823113 | hihealth@sina.com | China | 59 | 58 |
| Shandong Wadesen Biotechnology Co. LTD | 0531-88723173 18596073690 | 1047208234@qq.com | China | 3682 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | 027-027-59207852 13308628970 | buy@fortunachem.com | China | 2645 | 58 |
View Lastest Price from 5-Benzylidenehydantoin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-27 | 5-Benzylidene Hydantoin
3775-01-7
|
US $0.00 / kg | 25kg | 99% | 2000 | Shijiazhuang Donghua Jinlong Chemical Co., LTD | |
 |
2024-01-02 | 5-Benzylidenehydantoin
3775-01-7
|
US $200.00 / g | 100g | 98 | 5kg | Kindchem(Nanjing)Co.,Ltd | |
 |
2020-04-25 | 5-BENZYLIDENEHYDANTOIN
3775-01-7
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-Benzylidene Hydantoin
3775-01-7
- US $0.00 / kg
- 99%
- Shijiazhuang Donghua Jinlong Chemical Co., LTD
-
- 5-Benzylidenehydantoin
3775-01-7
- US $200.00 / g
- 98
- Kindchem(Nanjing)Co.,Ltd
-
- 5-BENZYLIDENEHYDANTOIN
3775-01-7
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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