ChemicalBook >> CAS DataBase List >>ST072042
ST072042
- CAS No.
- 88349-90-0
- Chemical Name:
- ST072042
- Synonyms
- A2793;ST072042;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
- CBNumber:
- CB53056845
- Molecular Formula:
- C13H12ClNO3
- Molecular Weight:
- 265.69
- MDL Number:
- MFCD04275530
- MOL File:
- 88349-90-0.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
ST072042 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0140439 | A2793 99.81% | 88349-90-0 | 5mg | $150 | 2021-12-16 | Buy |
| Matrix Scientific | 156285 | Ethyl [(5-chloroquinolin-8-yl)oxy]acetate | 88349-90-0 | 0.500g | $160 | 2021-12-16 | Buy |
| Matrix Scientific | 156285 | Ethyl [(5-chloroquinolin-8-yl)oxy]acetate | 88349-90-0 | 1g | $200 | 2021-12-16 | Buy |
| AK Scientific | 8921CZ | Ethyl[(5-chloroquinolin-8-yl)oxy]acetate | 88349-90-0 | 250mg | $248 | 2021-12-16 | Buy |
| ChemScene | CS-0140439 | A2793 99.81% | 88349-90-0 | 10mg | $250 | 2021-12-16 | Buy |
ST072042 Chemical Properties,Uses,Production
Biological Activity
A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK .
in vitro
A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
target
| Target | Value |
| mTRESK (Cell-free assay) | 6.8 μM |
ST072042 Preparation Products And Raw materials
Raw materials
Preparation Products
ST072042 Suppliers
Global( 30)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Yantai ShengKailun Chemical Technology Co., Ltd. | 13356901049 | 3119594100@qq.com | China | 7765 | 55 |
2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester
ethyl [(5-chloroquinolin-8-yl)oxy]acetate
ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate
ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate
ST072042
Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester
A2793
A2793,inhibit,Inhibitor,A-2793,TALK-1,TRESK,pain,KcsA,TASK-1,A 2793,Potassium Channel
88349-90-0