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ChemicalBook >> CAS DataBase List >>2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Structure
2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- structure
CAS No.
30388-31-9
Chemical Name:
2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-
Synonyms
2-cyano-3-[4-(diphenylamino)phenyl]prop-2-enoic acid;2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]-
CBNumber:
CB58603378
Molecular Formula:
C22H16N2O2
Molecular Weight:
340.37
MDL Number:
MOL File:
30388-31-9.mol
Last updated:2023-07-14 17:44:29
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2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Properties

Melting point 213-214 °C
Boiling point 546.6±45.0 °C(Predicted)
Density 1.280±0.06 g/cm3(Predicted)
pka -99.34±0.10(Predicted)

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Chemical Properties,Uses,Production

Description

DN-F01 is a potent cardiac sarcomere inhibitor, DNF01 targeting the cardiac muscle thin filament protein troponin complex. Functional studies show that DN-F01 has a strong inhibitory calcium-dependent effect on cardiac myofibrillar ATPase activity with an IC50 value of 11 ± 4 nmol/L. DN-F01 is shown to bind to a cardiac troponin C?troponin I chimera (cChimera) with a KD of ～50 nM using fluorescence spectroscopy, indicating that troponin is the likely target for DN-F01. NMR titrations of DNF01 to C35S and A-Cys cChimera show covalent and noncovalent binding of DN-F01 bound to the calcium-saturated cChimera.

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Istare Biotechnology Co., Ltd. 029-81530825 18682931470 2142355700@qq.com China 1454 58
Supplier Advantage
Shaanxi Istare Biotechnology Co., Ltd. 58
2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- 2-cyano-3-[4-(diphenylamino)phenyl]prop-2-enoic acid 30388-31-9