DL-PROPARGYLGLYCINE
- CAS No.
- 64165-64-6
- Chemical Name:
- DL-PROPARGYLGLYCINE
- Synonyms
- NSC21940;DL-Pra-OH;H-DL-PRA-OH;H-DL-Prg-OH;DL-PROPARGYL-GLY-OH;DL-PROPARGYLGLYCINE;DL-Gly(Propargyl)-OH;H-PROPARGYL-DL-GLY-OH;H-DL-GLY(PROPARGYL)-OH;H-PROPARGYL-DL-GLYCINE
- CBNumber:
- CB6140609
- Molecular Formula:
- C5H7NO2
- Molecular Weight:
- 113.11
- MDL Number:
- MFCD00056728
- MOL File:
- 64165-64-6.mol
- MSDS File:
- SDS
storage temp. | -20°C |
---|---|
solubility | Soluble in DMSO (up to 10 mg/ml) or in Water (up tp 10 mg/ml). |
form | Crystalline Powder |
color | White to off-white |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
FDA UNII | FU67PLJ48R |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P302+P352-P305+P351+P338 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
DL-PROPARGYLGLYCINE price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P7888 | DL-Propargylglycine cystathionine γ-lyase inhibitor | 64165-64-6 | 1g | $226 | 2024-03-01 | Buy |
Sigma-Aldrich | P7888 | DL-Propargylglycine cystathionine γ-lyase inhibitor | 64165-64-6 | 5g | $345.2 | 2024-03-01 | Buy |
Sigma-Aldrich | P7888 | DL-Propargylglycine cystathionine γ-lyase inhibitor | 64165-64-6 | 250mg | $77.4 | 2024-03-01 | Buy |
Usbiological | 287837 | DL-Propargylglycine | 64165-64-6 | 500mg | $333 | 2021-12-16 | Buy |
Chem-Impex | 07081 | DL-Propargylglycine,≥98% ≥98% | 64165-64-6 | 1G | $96.45 | 2021-12-16 | Buy |
DL-PROPARGYLGLYCINE Chemical Properties,Uses,Production
Description
Propargylglycine (64165-64-6) is an irreversible inhibitor of the hydrogen sulfide biosynthesis enzyme, cystathione-γ-lyase. It inhibits H2S production in rat liver preparations (IC50=55 μM) and inhibits the rise in plasma H2S in rats with hemorrhagic shock2. Propargylglycine reduces inflammation in a rodent carrageenan-induced hindpaw edema model3 and ameliorates gentamycin-induced nephrotoxicity1.
Chemical Properties
White to off-white powder
Uses
Dl-propargylglycine is an inhibitor of hydrogen sulfide (H2S) production.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 3484, 1954 DOI: 10.1021/ja01642a036
Tetrahedron Letters, 22, p. 1787, 1981 DOI: 10.1016/S0040-4039(01)90439-3
Biochem/physiol Actions
DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).
References
1) Dam et al. (2012), Inhibition of cystathione gamma-lyase and the biosynthesis of endogenous hydrogen sulphide ameliorates gentamicin-induced nephrotoxicity; Eur. J. Pharmacol., 685 165 2) Mok et al. (2004), Role of hydrogen sulphide in haemorrhagic shock in the rat: protective effect of inhibitors of hydrogen sulphide biosynthesis; Br. J. Pharmacol., 143 881 3) Bhatia et al. (2005),Hydrogen sulphide is a mediator of carrageenan-induced hindpaw edema in the rat; Br. J. Pharmacol., 145 141
DL-PROPARGYLGLYCINE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 13172 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
View Lastest Price from DL-PROPARGYLGLYCINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | DL-PROPARGYLGLYCINE
64165-64-6
|
US $10.00 / KG | 10KG | 99% | 100kg | Career Henan Chemical Co |
- DL-PROPARGYLGLYCINE
64165-64-6
- US $10.00 / KG
- 99%
- Career Henan Chemical Co
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