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BIBX 1382 DIHYDROCHLORIDE

BIBX 1382 DIHYDROCHLORIDE structure

CAS No.: 196612-93-8

Chemical Name:: BIBX 1382 DIHYDROCHLORIDE

Synonyms: Falnid;CS-928;Falnidamol;Unii-0mu316797d;Falnidamol [inn];BIBX 1382 DIHYDROCHLORIDE;FALNIDAMOL; BIBX-1382; BIBX 1382;8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine;N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine;N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine

CBNumber:: CB6842590

Molecular Formula:: C18H19ClFN7

Molecular Weight:: 387.84

MDL Number:: MFCD09838900

MOL File:: 196612-93-8.mol

MSDS File:: SDS

Last updated:2023-09-04 15:51:00

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BIBX 1382 DIHYDROCHLORIDE Properties

Melting point	>217°C (dec.)
Boiling point	552.0±60.0 °C(Predicted)
Density	1.427
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	8?+-.0.10(Predicted)
form	Solid
color	Pale Yellow to Yellow
FDA UNII	0MU316797D

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

BIBX 1382 DIHYDROCHLORIDE price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	324832	EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem	196612-93-8	5MG	$318	2024-03-01	Buy
Cayman Chemical	29630	BIBX1382	196612-93-8	1mg	$34	2024-03-01	Buy
Cayman Chemical	29630	BIBX1382	196612-93-8	25mg	$576	2024-03-01	Buy
Cayman Chemical	29630	BIBX1382	196612-93-8	5mg	$150	2024-03-01	Buy
Cayman Chemical	29630	BIBX1382	196612-93-8	10mg	$280	2024-03-01	Buy

Product number	Packaging	Price	Buy
324832	5MG	$318	Buy
29630	1mg	$34	Buy
29630	25mg	$576	Buy
29630	5mg	$150	Buy
29630	10mg	$280	Buy

BIBX 1382 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Falnidamol is a novel ErbB receptor kinase inhibitor that is more potent at inhibiting signaling induced by TGF-α than that induced by neuregulin1-β1 or anti-ErbB2 agonist antibodies.

Uses

BIBX 1382 Dihydrochloride, is a potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM).

Definition

ChEBI: N4-(3-chloro-4-fluorophenyl)-N6-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-4,6-diamine is a substituted aniline.

Biological Activity

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays > 1000-fold lower potency against ErbB2 (IC 50 = 3.4 μ M) and a range of other related tyrosine kinases (IC 50 > 10 μ M). Oral administration inhibits growth of established human xenografts in athymic mice.

References

1. f. f. solca, a. baum, e. langkopf, g. dahmann, k. h. heider, f. himmelsbach and j. c. van meel, j pharmacol exp ther 2004, 311, 502-509.

BIBX 1382 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

BIBX 1382 DIHYDROCHLORIDE Suppliers

Global( 65)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69

View Lastest Price from BIBX 1382 DIHYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-31	BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride 196612-93-8	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride
196612-93-8
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

BIBX 1382 DIHYDROCHLORIDE Spectrum

BIBX 1382 DIHYDROCHLORIDE(196612-93-8)¹HNMR

196612-93-8(BIBX 1382 DIHYDROCHLORIDE)Related Search:

Piperidin-4-yl-pyrimidin-2-yl-amine dihydrochloride BIBX 1382 DIHYDROCHLORIDE

BIBX 1382 DIHYDROCHLORIDE 8-(3-Chloro-4-fluoroanilino)-2-((1-methyl-4-piperidyl)amino)pyrimido(5,4-D)pyrimidine Falnidamol Falnidamol [inn] Pyrimido(5,4-D)pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)- Unii-0mu316797d N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride Falnid N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)pyrimido[5,4-d]pyrimidine-2,8-diamine BIBX 1382 N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine N4-(3-chloro-4-fluoro-phenyl)-N6-(1-methyl-4-piperidyl)pyrimido[5,4-d]pyrimidine-4,6-diamine N8-(3-CHLORO-4-FLUOROPHENYL)-N2-(1-METHYL-4-PIPERIDINYL)-PYRIMIDO[5,4-D]PYRIMIDINE-2,8-DIAMINE DIHYDROCHLORIDE FALNIDAMOL; BIBX-1382; BIBX 1382 BIBX 1382 dihydrochloride,N8-(3-Chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-pyrimido[5,4-d]pyrimidine-2,8-diaminedihydrochloride CS-928 196612-93-8 C18H19ClFN7 C18H21Cl3FN7 C18H19ClFN72HCl