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trisethyleneiminoquinone

trisethyleneiminoquinone structure

CAS No.: 68-76-8

Chemical Name:: trisethyleneiminoquinone

Synonyms: TEIB;A 163;Trenimon;prenimon;riker 601;oncovedex;TRENIMONE;NSC-29215;bayer 3231;10257 R.P.

CBNumber:: CB6875606

Molecular Formula:: C12H13N3O2

Molecular Weight:: 231.25052

MDL Number:: MFCD00866557

MOL File:: 68-76-8.mol

MSDS File:: SDS

Last updated:2022-12-21 16:56:50

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trisethyleneiminoquinone Properties

Melting point	162.5-163°
Boiling point	373.33°C (rough estimate)
Density	1.1818 (rough estimate)
refractive index	1.5290 (estimate)
FDA UNII	F3D5D9P25I
IARC	3 (Vol. 9, Sup 7) 1987
ATC code	L01AC02
EPA Substance Registry System	Triaziquone (68-76-8)

SAFETY

Risk and Safety Statements

RIDADR	3249
HazardClass	6.1(a)
PackingGroup	II
Toxicity	An antineoplastic agent related to thiotepa. It has considerable acute toxicity and is a probable carcinogen.

trisethyleneiminoquinone Chemical Properties,Uses,Production

Originator

Trenimon,Bayer

Uses

Alkylating reagent in mutation research.

Definition

ChEBI: A member of the class of 1,4-benzoquinones that is 1,4-benzoquinone in which three of the ring hydrogens are replaced by aziridin-1-yl groups.

Manufacturing Process

Under anaerobic conditions including an atmosphere of nitrogen, 104 ml (2.0 moles) of aziridine is added as a single portion with stirring to a suspension of 33.6 g (0.2 mole) of 2,6-dimethoxy-1,4-benzoquinone in 500 ml of absolute methanol at a temperature of 0° to 5°C. After the addition has been 2,6- dimethoxy-1,4-benzoquinone completed the external cooling of the reaction vessel is replaced by a room temperature water bath and the mixture is stirred at room temperature for 45 hours while a slow stream of nitrogen is passed therethrough to preserve the anaerobic reaction conditions. It is found that the yellow starting material, during this period, completely disappears into solution and that a violet or purple substance together with a colorless substance are formed as precipitated reaction products. This mixture of precipitated products is removed by filtration at -20°C and the residue is washed with a small quantity of cooled methanol. Then the mixture is dried in a vacuum desiccator yielding about 30.4 g of mixed product. The mixed product is extracted with benzene whereby the violet or purple colored component passes into solution and the substantially colorless product remains in a yield of about 16.0 g. The colorless 2,6-bis-aziridino-l,4- benzohydroquinone so obtained melts with decomposition at about 221-222°C with melting starting at about 200°C. It can be purified by recrystallization from a of dioxane yielding snow-white crystals that decompose when heated at 222-224°C while starting to melt at 220°C. The benzene extract of the colored reaction product is evaporated to dryness under vacuum, yielding a residue melting at 161-162°C which is recrystallized from 200 ml of ethyl acetate, filtered under suction at -20°C, washed with cold methanol and thus yields about 11.5 g of a pure, purple-colored crystalline 2,3,5-tris-aziridino-1,4-benzoquinone melting at 162.5-163°C.

Therapeutic Function

Antineoplastic

General Description

Purple needle-like crystals.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

trisethyleneiminoquinone is an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data is not available for trisethyleneiminoquinone, but trisethyleneiminoquinone is probably combustible.

Safety Profile

Poison by intraperitoneal, intravenous, and parenteral routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Used as a drug for the treatment of neoplastic dseases.

trisethyleneiminoquinone Preparation Products And Raw materials

Raw materials

1,4-Benzoquinone 2-Chloro-4,6-dimethoxy-1,3,5-triazine Ethyleneimine 2,6-DIMETHOXY-1,4-BENZOQUINONE

Preparation Products

trisethyleneiminoquinone Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9340	55
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27644	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9020	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Chizhou Kailong Import and Export Trade Co., Ltd.		xg01_gj@163.com	China	9503	50
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	15229059051	1027@dideu.com	China	9947	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
Hubei xin bonus chemical co. LTD	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Shaanxi Didu New Materials Co. Ltd	58
TargetMol Chemicals Inc.	58
BOC Sciences	65
Chizhou Kailong Import and Export Trade Co., Ltd.	50
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	58
TargetMol Chemicals Inc.	58

View Lastest Price from trisethyleneiminoquinone manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-06	trisethyleneiminoquinone USP/EP/BP 68-76-8	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
	2021-01-06	trisethyleneiminoquinone 68-76-8	US $1.80 / KG	1g	96%-99%	1kg/10kg/100kg	Career Henan Chemica Co

trisethyleneiminoquinone USP/EP/BP
68-76-8
US $1.10 / g
99.9%
Dideu Industries Group Limited

trisethyleneiminoquinone
68-76-8
US $1.80 / KG
96%-99%
Career Henan Chemica Co

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