メチルフェニデート

メチルフェニデート 化学特性,用途語,生産方法

効能

中枢神経刺激薬

来歴

Methylphenidate is a piperidine derivative that is a central nervous system stimulant. Methylphenidate, in its hydrochloride form, is the active ingredient in the common medication Ritalin. Methylphenidate was first synthesized from benzyl cyanide and 2-chloropyridine in Basel, Switzerland in 1944 by Ciba chemist Leandro Panizzon (1907 ?).
Panizzon named the substance Ritaline after his wife, whose nickname was Rita. Panizzon and Max Hartmann proposed an improved synthesis for methylphenidate and obtained a U.S. patent for its preparation in 1950 (U.S. Patent Number 2507631). In 1954, methylphenidate was patented for use as an agent for treating psychological disorders under the name Ritalin by the Ciba pharmaceutical company.(Ciba subsequently merged with the Geigy company to become Ciba-Geigy, and then Ciba-Geigy merged with Sandoz to form Novartis.) Methylphenidate was first used to reverse drug-induced coma. Ritalin was approved by the Food and Drug Administration (FDA) in 1955 and introduced in the United States in 1956 for several conditions including depression, senile behavior, lethargy, and narcolepsy.
Hyperactive children were first treated with stimulants in 1937. Since methylphenidate first appeared on the market, its use for treating ADHD has steadily increased. It is the most commonly used medication for treating children diagnosed with ADHD.

使用

Stimulant.

世界保健機関（WHO）

Methylphenidate, a piperidine derivative with mild central stimulant activity, was introduced in 1956. Its pharmacological properties resemble those of amfetamines and it shares their abuse potential. Methylphenidate retains a place as an adjunct in the treatment of hyperkinetic syndromes in both children and adults. It is controlled under Schedule II of the 1971 Convention on Psychotropic Substances. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)

安全性プロファイル

Poison experimentally by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic to humans by intravenous route. Human systemic effects by intravenous route: dyspnea. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.

メチルフェニデート 上流と下流の製品情報

原材料

準備製品

113-45-1(メチルフェニデート)キーワード:

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• 113-45-1
• meridil
• Methyl alpha-phenyl-2-piperdine acetate
• methyl alpha-phenyl-2-piperidylacetate
• Methyl phenidyl acetate
• 2-Piperidineacetic acid, α-phenylmethyl ester
• Methyl-α-phenyl-2-piperidineacetate
• 2-Piperidineacetic acid, .alpha.-phenyl-, methyl ester
• 2-Piperidineacetic acid, a-phenyl-, methyl ester (6CI, 8CI, 9CI)
• 4311/b Ciba
• a-Phenyl-2-piperidineacetic acid methyl ester
• Calocain
• Methyl a-phenyl-a-2-piperidinylacetate
• Methyl a-phenyl-a-2-piperidylacetate
• Methylphenidate (base and/or unspecified salts)
• C07196
• OROS methylphenidate
• 2-phenyl-2-(2'-piperidyl)acetic acid Methyl ester
• methyl 2-phenyl-2-(piperidin-2-yl)acetate hydrochloride
• Methyl phenyl(2-piperidinyl)acetate
• DUGOZIWVEXMGBE-UHFFFAOYSA-N
• Ritalin USP/EP/BP
• alpha-Phenyl-2-piperidineacetic acid methyl ester
• Phenidylate
• Methylphenidan
• DEXMETHYLPHENIDATE
• Rubifen
• methyl 2-phenyl-2-(piperidin-2-yl)acetate
• 2-Piperidineacetic acid, α-phenyl-, methyl ester
• メチルフェニデート
• メチル 2-フェニル-2-(ピペリジン-2-イル)アセタート
• α-フェニル-α-(2-ピペリジル)酢酸メチル
• α-フェニル-2-ピペリジン酢酸メチル
• メチルフェニダート
• メチルフェニダン
• メリジル
• 2-フェニル-2-(2-ピペリジル)酢酸メチル
• α-フェニルピペリジン-2-酢酸メチル
• フェニジラート
• (2-ピペリジニル)フェニル酢酸メチル
• カロカイン