Nitrazolam

 化学構造式
28910-99-8
CAS番号.
28910-99-8
化学名:
别名:
英語名:
Nitrazolam
英語别名:
NitrazolaM;Nitrazolame;Nitrazolam 98%;1-Methyl-8-nitro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene;1-Methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 1-methyl-8-nitro-6-phenyl-;1-methyl-8-nitro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
CBNumber:
CB22681342
化学式:
C17H13N5O2
分子量:
319.32
MOL File:
28910-99-8.mol

Nitrazolam 物理性質

沸点 :
550.2±60.0 °C(Predicted)
比重(密度) :
1.44±0.1 g/cm3(Predicted)
溶解性:
DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml
酸解離定数(Pka):
1.96±0.40(Predicted)
外見 :
Solid
色:
Yellow
InChI:
InChI=1S/C17H13N5O2/c1-11-19-20-16-10-18-17(12-5-3-2-4-6-12)14-9-13(22(23)24)7-8-15(14)21(11)16/h2-9H,10H2,1H3
InChIKey:
OYRPNABWTHDOFK-UHFFFAOYSA-N
SMILES:
N12C(C)=NN=C1CN=C(C1=CC=CC=C1)C1=CC([N+]([O-])=O)=CC=C12

安全性情報

Nitrazolam 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Nitrazolam 化学特性,用途語,生産方法

説明

Nitrazolam is classified as a novel benzodiazepine, although its synthesis and activity have been previously described in the literature. Benzodiazepines are central nervous system depressants. Novel benzodiazepines, often pirated from early drug discovery or pharmaceutical studies, have appeared on the novel and illicit drug markets in recent years. These substances have caused adverse events, including deaths, as described in the literature. Nitrazolam is structurally similar to traditional benzodiazepines nitrazepam and alprazolam, Schedule IV substances in the United States, as well as the novel benzodiazepines flunitrazolam and clonazelam. 

臨床応用

Nitrazolam is primarily used as an anticonvulsant in children. It is also still used in the most severe and debilitating cases of insomnia in an inpatient setting or in short term outpatient treatment. Hypnotic benzodiazepines estazolam and nitrazepam are used more frequently than nimetazepam for this purpose. The foremost use of Nitrazepam is to treat insomnia, which includes an inability to fall asleep and waking up at night regularly. It’s also prescribed for restless legs syndrome, anxiety disorder, and depression. 

Nitrazolam 上流と下流の製品情報

原材料

準備製品


Nitrazolam 生産企業

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  • 28910-99-8
  • 1-methyl-8-nitro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
  • 1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
  • 1-Methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
  • NitrazolaM
  • Nitrazolam 98%
  • Nitrazolame
  • 1-Methyl-8-nitro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 1-methyl-8-nitro-6-phenyl-
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