Nitrazolam

Nitrazolam Struktur
28910-99-8
CAS-Nr.
28910-99-8
Englisch Name:
Nitrazolam
Synonyma:
NitrazolaM;Nitrazolame;Nitrazolam 98%;1-Methyl-8-nitro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene;1-Methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine;1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 1-methyl-8-nitro-6-phenyl-;1-methyl-8-nitro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
CBNumber:
CB22681342
Summenformel:
C17H13N5O2
Molgewicht:
319.32
MOL-Datei:
28910-99-8.mol

Nitrazolam Eigenschaften

Siedepunkt:
550.2±60.0 °C(Predicted)
Dichte
1.44±0.1 g/cm3(Predicted)
Löslichkeit
DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml
pka
1.96±0.40(Predicted)
Aggregatzustand
Solid
Farbe
Yellow
InChI
InChI=1S/C17H13N5O2/c1-11-19-20-16-10-18-17(12-5-3-2-4-6-12)14-9-13(22(23)24)7-8-15(14)21(11)16/h2-9H,10H2,1H3
InChIKey
OYRPNABWTHDOFK-UHFFFAOYSA-N
SMILES
N12C(C)=NN=C1CN=C(C1=CC=CC=C1)C1=CC([N+]([O-])=O)=CC=C12

Sicherheit

Nitrazolam Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nitrazolam is classified as a novel benzodiazepine, although its synthesis and activity have been previously described in the literature. Benzodiazepines are central nervous system depressants. Novel benzodiazepines, often pirated from early drug discovery or pharmaceutical studies, have appeared on the novel and illicit drug markets in recent years. These substances have caused adverse events, including deaths, as described in the literature. Nitrazolam is structurally similar to traditional benzodiazepines nitrazepam and alprazolam, Schedule IV substances in the United States, as well as the novel benzodiazepines flunitrazolam and clonazelam. 

Clinical Use

Nitrazolam is primarily used as an anticonvulsant in children. It is also still used in the most severe and debilitating cases of insomnia in an inpatient setting or in short term outpatient treatment. Hypnotic benzodiazepines estazolam and nitrazepam are used more frequently than nimetazepam for this purpose. The foremost use of Nitrazepam is to treat insomnia, which includes an inability to fall asleep and waking up at night regularly. It’s also prescribed for restless legs syndrome, anxiety disorder, and depression. 

Nitrazolam Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nitrazolam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • 1-methyl-8-nitro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
  • 1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
  • 1-Methyl-8-nitro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
  • NitrazolaM
  • Nitrazolam 98%
  • Nitrazolame
  • 1-Methyl-8-nitro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 1-methyl-8-nitro-6-phenyl-
  • 28910-99-8
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