クロロアセトアルデヒド 化学特性,用途語,生産方法
用途
防カビ剤、殺菌剤、有機合成中間体
化学的特性
Chloroacetaldehyde is a combustible, colorless liquid with a very sharp, irritating odor.
物理的性質
Clear, colorless liquid with an irritating, acrid odor
使用
Chloroacetaldehyde is used in the productionof 2-aminothiazole.
定義
ChEBI: Chloroacetaldehyde is acetaldehyde substituted at C-2 by chlorine. It derives from an acetaldehyde.
一般的な説明
A clear colorless liquid with a pungent odor. Flash point about 190°F. Corrosive to skin and mucous membranes. Chloroacetaldehyde is very toxic by inhalation.
空気と水の反応
Soluble in water. Forms an insoluble hemihydrate at greater than 50% concentration.
反応プロフィール
Chloroacetaldehyde polymerizes on standing. At greater than 50% concentration in water, Chloroacetaldehyde forms an insoluble hemihydrate. Sensitive to heat. Reacts with oxidizing agents. Incompatible with acids and water . Burns to give poisonous and irritating gases.
危険性
Corrosive to skin and mucous membranes.
TLV: ceiling 1 ppm.
健康ハザード
Chloroacetaldehyde is a highly toxic andcorrosive compound that can injure the eyes,skin, and respiratory system. Exposure toits vapor at high concentrations can producesevere irritation and impair vision. At lowconcentrations, the vapor can cause irritationand sore eyelids. Brief contact with 40%aqueous solution can result in skin burn anddestruction of tissues. A 0.5% dilute solutioncan still be irritating on skin.
Inhalation of its vapor at the 5-ppm levelcan irritate the eyes, nose, and throat. Ingestionmay result in pulmonary edema. Swallowinga concentrated solution may be fatal.The acute toxicity data are as follows:
LD50 value, intraperitoneal (rats): 2 mg/kg
LD50 value, oral (rats): 23 mg/kg
LD50 value, skin (rabbits): 67 mg/kg
This compound is a mutagen, testing positivein the Ames test.
火災危険
Combustible; flash point (closed cup) 87.8°C
(190°F); flash point of 50% aqueous solution
53°C (128°F) (at this concentration it may
form insoluble hemihydrate); it forms an
explosive mixture with air. Reactions with
strong acids and oxidizers are exothermic.
安全性プロファイル
Suspected carcinogen.
Poison by ingestion, skin contact, and
intraperitoneal routes. Mutation data
reported. Combustible when exposed to
heat or flame. Reacts with oxidizing
materials. To fight fire, use water, foam,
CO2, dry chemical. When heated to
decomposition it emits toxic fumes of Cl-.
See also ALDEHYDES and CHLORIDES.
職業ばく露
Chloroacetaldehyde is used as a fungicide; as an intermediate in 2-aminothiazole manufacture;
and in bark removal from tree trunks.
発がん性
Chloroacetaldehyde has been reported to
be an inhibitor of DNA synthesis and to form
DNA adducts; it is mutagenic in Salmonella
typhimurium and in Chinese hamster cells.
Limited in vivo genotoxicity studies with
chloroacetaldehyde were negative.
環境運命予測
Chemical/Physical. Polymerizes on standing (Windholz et al., 1983).
輸送方法
UN22322-Chloroethanal, Hazard class: 6.1;
Labels: 6.1-Poison Inhalation Hazard, Inhalation Hazard
Zone B.
不和合性
Heat and water sensitive; concentrations
of .50% form insoluble hemihydrate material on contact
with water. Reacts with oxidizers, acids. On heating,chloroacetaldehyde releases chlorine fumes. Polymerizable
upon standing
廃棄物の処理
Incineration, preferably after
mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove
the halo acids produced.
クロロアセトアルデヒド 上流と下流の製品情報
原材料
準備製品
5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%
N-フェニル-N'-(1,2,3-チアジアゾール-5-イル)尿素
2-アミノチアゾール
2-アミノチアゾリン 塩酸塩
2-イソブチルチアゾール
2H-フロ[2,3-h][1]ベンゾピラン-2-オン
1,2,3-チアジアゾール-5-アミン
アミノアセタール
6-ブロモイミダゾ[1,2-A]ピリジン
6,8-ジブロモイミダゾ[1,2-a]ピラジン
イミダゾ[1,2-b]ピリダジン
2-ヒドロキシ-3-クロロプロパン酸
6-フルオロイミダゾ[1,2-A]ピリジン
チアゾール-2(3H)-オン
2-メチルフラン-3-カルボン酸メチル
4-(2-クロロエチル)モルホリン
(1,3-チアゾール-2-イルメチル)アミン
イミダゾ[1,2-A]ピリジン-6-カルボン酸メチル