グリブゾール 化学特性,用途語,生産方法
効能
糖尿病治療薬, 血糖降下薬
Originator
Gludease,Kyowa Hakko,Japan,1972
Manufacturing Process
15.7 g of 2-amino-5-tert-butyl-1,3,4-thiadiazole (0.1 mol) and 17.6 g of
benzene sulfonyl chloride (0.1 mol) were dissolved in 150 ml dry pyridine and
heated over steam for 4 hr. The pyridine was removed by distillation under
reduced pressure and the residue treated with 50 ml 2N HCl. The solid
product, MP 162° to 163°C. was filtered off and recrystallized once from
benzene and twice from 50% aqueous EtOH.
Therapeutic Function
Oral hypoglycemic
グリブゾール 上流と下流の製品情報
原材料
準備製品