Venlafaxine hydrochloride, a novel phenethylamine derivative, was introduced in
the U.S.A. as an antidepressant. Venlafaxine is reported to be the first in the class
of the second-generation of antidepressants with dual serotonidnorepinephrine
reuptake inhibitory activity. Venlafaxine lacks any affinity for muscarinic,
cholinergic, histaminergic and noradrenergic receptors and therefore, has an
unusually favorable side effect profile compared with classical tricyclic
antidepressants and shows less cardiotoxicity. In addition, venlafaxine has a rapid
onset of action that makes it unique among the antidepressant agents. Other
indications for venlafaxine include the treatment of obsessive and panic disorders,
and obesity. Both enantiomers of venlafaxine were reported to have similar
biological activity.
화학적 성질
White Crystalline Powder
용도
A selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
일반 설명
A Certified Snap-N-Spike? Solution suitable for many LC/MS and GC/MS applications from forensic or clinical toxicology analysis to urine drug testing. Also known by the brand name Effexor?, venlafaxine is an SNRI antidepressant approved for the treatment of major depressive and general anxiety disorders.
생물학적 활성
Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (K i values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.
