눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P312
불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P313
의사의 진료/치료를 받을 것
P337+P313
눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P403+P233
용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
Biapenem C화학적 특성, 용도, 생산
개요
Biapenem was introduced in Japan as a parenteral treatment for bacterial
infections. This new 1-β-methylcarbapenem can be prepared by reaction of commercially
available 4-nitrobenzyl protected β-methylcarbapenem enolphosphate with mercapto
bicyclotriazolium chloride, obtained in 11 steps starting from hydrazine, followed by
deprotection of the carboxylic acid function. Biapenem is a bacterial cell wall synthesis
inhibitor with a broad spectrum in vitro antibacterial activity encompassing many Gramnegative
and Gram-positive aerobic and anaerobic bacteria, including species producing
β-lactamases. Like imipenem, biapenem is moderately active against fnferococcus
faecalis and E. faecuirn and is inactive against methicillin-resistant Staphylococcus aureus.
Biapenem is stable to hydrolysis by human renal dihydropeptidase I (DHP-I) and therefore
does not require the coadministration of a DHP-I inhibitor. In clinical trials, biapenem
showed good clinical and microbiological efficacy in the treatment of patients with intraabdominal,
lower respiratory tract and complicated urinary tract infections. After
intravenous administration, the drug is widely distributed, has linear pharmacokinetics and
is mainly excreted in the urine with an elimination half-life of approximately 1 h. Biapenem
is generally well tolerated, the most common adverse events being skin eruptions/rashes,
nausea and diarrhea.
화학적 성질
Off-White Solid
용도
Biapenem is a carbapenem antibiotic. It has in vitro activity against anaerobes. Biapenem is a new parenteral carbapenem antibacterial agent with a broad spectrum of in vitro antibacterial activity encompassing many Gram-negative and Gram-positive aerobic
Antimicrobial activity
A semisynthetic carbapenem with a 2-substituted triazolium
moiety. It has broad-spectrum activity against most aerobic
and anaerobic Gram-positive and Gram-negative organisms.
It is equivalent to, or slightly more active than, imipenem
against Gram-negative aerobic bacteria and slightly less active
than imipenem against Gram-positive organisms. It is stable
to hydrolysis by dehydropeptidase. It is not hydrolyzed by
most serine β-lactamases, but like all carbapenems and penems
is readily hydrolyzed by carbapenemases. It penetrates
into bronchial epithelial lining fluid with peak concentrations
of 2.4–4.4 mg/L. The plasma half-life is 1.5–1.9 h. The potential
for neurotoxicity is less than that of imipenem.
Clinical Use
Biapenem is a newer second-generation carbapenem withchemical and microbiological properties similar to those ofmeropenem. Thus, it has broad-spectrum antibacterial activitythat includes most aerobic Gram-negative and Grampositivebacteria and anaerobes. Biapenem is stable toDHP-I67 and resistant to most β-lactamases. It is claimedto be less susceptible to metallo-β-lactamases than eitherimipenem or meropenem. It is not active orally.
