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Ramipril

Ramipril 구조식 이미지

카스 번호:: 87333-19-5

상품명:: Ramipril

동의어(영문):: ALTACE;RaMipril API;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;2-[[1-(2-ethoxycarbonyl-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-1-oxopropan-2-yl]amino]-4-phenylbutanoic acid;DELIX;vesdil;Trimce;RAMACE;Triatec;UNIPRIL

CBNumber:: CB0249104

분자식:: C23H32N2O5

포뮬러 무게:: 416.51

MOL 파일:: 87333-19-5.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 427

Ramipril 속성

녹는점: 106-108°C

끓는 점: 616.2±55.0 °C(Predicted)

알파: D24 +33.2° (c = 1 in 0.1N ethanolic HCl)

밀도: 1.200±0.06 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: DMSO: ~18mg/mL

산도 계수 (pKa): pKa 3.30±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain);5.75±0.00(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)

물리적 상태: 가루

색상: 하얀색

BCS Class: 1

CAS 데이터베이스: 87333-19-5(CAS DataBase Reference)

안전

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/38
안전지침서	26-37/39
WGK 독일	2
RTECS 번호	GY5879600
HS 번호	2933995300
유해 물질 데이터	87333-19-5(Hazardous Substances Data)
독성	LD50 (14 day) in male, female mice, male, female rats (mg/kg): 1194, 1158, 687, 608 i.v.; 10933, 10048, >10000, >10000 orally (Donaubauer, Mayer)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드

예방조치문구:

P201	사용 전 취급 설명서를 확보하시오.
P202	모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P308+P313	노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405	밀봉하여 저장하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
2		0

Ramipril MSDS

Ramipril

Ramipril C화학적 특성, 용도, 생산

개요

Ramipril, a prodrug of ramiprilat, is a long-acting, tissue-specific and non-sulfhydryl ACE inhibitor useful in the treatment of mild to moderate hypertension. In animal studies ramipril exerted cardioprotective effects resembling those of bradykinin in cardiac reperfusion injuries. Ramipril is also reportedly useful in congestive heart failure.

화학적 성질

White Solid

용도

Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]

정의

ChEBI: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

일반 설명

Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), ishydrolyzed to ramiprilat, its active diacid form, faster thanenalapril is hydrolyzed to its active diacid form. Peak serumconcentrations from a single oral dose are achieved between1.5 and 3 hours. The ramiprilate formed completely suppresses ACE activity for up to 12 hours, with 80% inhibitionof the enzyme still observed after 24 hours.

Ramipril 준비 용품 및 원자재

원자재

Ethyl 3-benzoylacrylate Palladium carbon fine chemical catalyzer Benzyl ester 사이클로헥세인 L-알라닌 사이클로펜텐 초산에틸 디클로로메탄 아세트산(빙초산) 메틸 프로피오네이트 피롤리딘 포름아미드 2-아자비시클로[3.3.0]옥탄-3-카르복실산 Benzenebutanoic acid, α-[[(1S)-2-chloro-1-methyl-2-oxoethyl]amino]-, ethyl ester, hydrochloride (αS)- 2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER Ethyl (S)-2-[(S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]-4-phenylbutyrate

준비 용품

(2R,3aR,6aR)-라미프릴

Ramipril 공급 업체

글로벌( 427)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Duling International Trade Co. LTD	+8617333973358	sales01@hbduling.cn	China	15664	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	985	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18219	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1142	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21688	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58

Ramipril 관련 검색:

노르말옥탄 2,2,4-트리메칠펜탄 1-옥탄술폰 산, 나트륨 염 폴리(옥시프로필렌)디아민 니켈카르보닐 Valsartan RAMIPRIL IMPURITY B RAMIPRIL IMPURITY C (S,S,S)-2-Azabicyclo[3,3,0]-octane-carboxylic acid benzylester hydrochloride Carbonyl iron powder ENDO, CIS-2-AZABICYCLO [3,3,0] OCTANE-3-CARBORYLIC ACID BENZYL ESTER HYDROCHLORIDE (FOR RAMIPRIL) Ramipril Related Compound B Ramiprilat RAMIPRIL IMPURITY A Ritonavir Related Compounds Mixture Ramipril Diketopiperazine RAMIPRIL RELATED COMPOUND B (20 MG) (RAMIPRIL ISOPROPYLESTER) 2-[N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-(1S,3S,5S)-2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID, BENZYL ESTER