칸타리딘
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칸타리딘 속성
- 녹는점
- 215-217 °C (lit.)
- 끓는 점
- 253.08°C (rough estimate)
- 밀도
- 1.0357 (rough estimate)
- 굴절률
- 1.4699 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO(25 mg/ml), 아세톤(8 mg/ml), 에탄올(8 mg/ml), 클로로포름(1:65), 에테르(1:560) 및 에틸 아세테이트(1:150)에 용해됩니다.
- 물리적 상태
- 액체
- 색상
- 하얀색
- 수용성
- 30mg/L(20℃)
- Merck
- 14,1752
- 안정성
- 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 2주 동안 보관할 수 있습니다.
- InChIKey
- DHZBEENLJMYSHQ-XCVPVQRUSA-N
- LogP
- -0.409 (est)
- CAS 데이터베이스
- 56-25-7(CAS DataBase Reference)
- IARC
- 3 (Vol. 10, Sup 7) 1987
- NIST
- Cantharidin(56-25-7)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+,T | ||
---|---|---|---|
위험 카페고리 넘버 | 28-36/37/38-38-37-36-23/24/25 | ||
안전지침서 | 53-45-36/37/39 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 1 | ||
WGK 독일 | 3 | ||
RTECS 번호 | RN8575000 | ||
TSCA | Yes | ||
위험 등급 | 6.1(a) | ||
포장분류 | I | ||
HS 번호 | 29329990 | ||
유해 물질 데이터 | 56-25-7(Hazardous Substances Data) |
칸타리딘 C화학적 특성, 용도, 생산
화학적 성질
Cantharidin is a brown to black powder.용도
Cantharidin is a natural toxin produced by blister beetles that moderately inhibits protein phosphatases 1 (PP1) (IC50 = 1.7 μM) and PP2A (IC50 = 0.2 μM) and only weakly inhibits the activity of PP2B (IC50 = 1 mM). It has been shown to stimulate cell cycle progression and induce premature mitosis, used topically (0.7%) as an anti-wart treatment, and has been shown to be active in cervical, tongue, neuroblastoma, bone, leukemia, ovarian, colon, and various other cancer cell lines.정의
ChEBI: A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.Indications
Cantharidin, from the beetle Cantharis vesicatoria, causes intraepidermal vesiculation and is used in the treatment of warts and other benign cutaneous lesions. Cantharidin is extremely toxic if taken internally; it should not be prescribed for at-home use.Cantharidin (Cantharone), a mitochondrial poison derived from the blister beetle Cantharis vesicatoria, leads to changes in cell membranes, epidermal cell dyshesion, acantholysis, and blister formation and is also useful. Cantharidin can be compounded with salicylic acid and podophyllin resin; occlusion for only 2 hours is needed with this combination. Thick hyperkeratotic lesions should be pared down before painting. The lesion should then be painted with cantharidin, allowed to dry, and covered with Blenderm or other nonporous occlusive tape; 40% salicylic acid plaster may be used to achieve greater activity. The tape is left on for 24 hours or until the area begins to hurt. A blister, often hemorrhagic, will form, break, crust, and fall off in 7 to 14 days; at this time, the lesion is pared down, and any wart remnants are retreated. Because the effect of cantharidin is entirely intraepidermal, no scarring ensues. Ring-like or "donut configuration" recurrences may be seen occasionally after treatment with cantharidin or, at times, following liquid nitrogen therapy. Owing to this agent’s toxicity, application by a physician is recommended. Verrusol, which contains 30% salicylic acid, 5% podophyllin, and 1% cantharidin, may be used in the same manner.
일반 설명
Brown to black powder or plates or scales. Formerly used as a counterirritant and vesicant. Used for the removal of warts. Used as an experimental anti tumor agent. Active ingredient in spanish fly, a reputed aphrodisiac.반응 프로필
Organic anhydrides, such as Cantharidin, are incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.위험도
Extremely toxic; questionable carcinogen; powerful irritant to all cells and tissues; deadly poi- son; respiratory failure; death.건강위험
Cantharidin is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste of less than 7 drops for a 70 kg (150 lb.) person. It is very toxic by absorption through skin.화재위험
When heated to decomposition Cantharidin emits acrid smoke and irritating fumes.생물학적 활성
Natural toxin inhibitor of protein phosphatases 1 and 2A (K i values are 1.1 and 0.19 μ M respectively); similar to okadaic acid (9,10-Deepithio-9,10-didehydroacanthifolicin ). Displays > 500-fold selectivity over PP2B.잠재적 노출
Formerly used as a counterirritant and vesicant. Also used for the removal of benign epithelial growths, e.g., warts. Used as an experimental antitumor agent. The active ingredient in “Spanish fly,” a reputed aphrodisia운송 방법
Cantharidin is not specifically listed in the DOT Performance-Oriented Packaging Standards with respect to labeling requirements or restrictions on shipping quantities.폐기물 처리
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.칸타리딘 준비 용품 및 원자재
원자재
Concentrated hydrochloric acid
drum
green tea
스테아린산 마그네슘
Pioneer Blue Natural Rubber Latex Gloves, Size 9
FATS 동물성, MIXED WITH 식물성 기름, 메틸 에스테르, 황화된
1H,3H-4,7-Epoxy-3a,7a-(methanothiomethano)isobenzofuran-1,3-dione, tetrahydro-, (3aR,4R,7S,7aS)-rel-
규산 마그네슘
3,4-Thiophenedicarboxylic acid, 2,5-dihydro-, dimethyl ester
3,4-Thiophenedicarboxylic acid, 2,5-dihydro-
티에노[3,4-c]푸란-1,3(4H,6H)-디온
3-Thiophenecarboxylic acid, 4-cyanotetrahydro-4-hydroxy-, methyl ester
Methyl 4-oxotetrahydrothiophene-3-carboxylate
디메틸3-티아아디페이트
푸란
준비 용품
칸타리딘 공급 업체
글로벌( 242)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12470 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32715 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8829 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |