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Nimodipine

Nimodipine 구조식 이미지

카스 번호:: 66085-59-4

상품명:: Nimodipine

동의어(영문):: NIMOTOP;2-methyo-xyethyl 1-methylethyl ester;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-(2-methoxyethyl) ester;Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester;ADMON;PERIPLUM;Nimodipin;Nimodipime;NIMODIPINE;BAY E 9736

CBNumber:: CB1398087

분자식:: C21H26N2O7

포뮬러 무게:: 418.44

MOL 파일:: 66085-59-4.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 406

Nimodipine 속성

녹는점: 125°C

끓는 점: 536.21°C (rough estimate)

밀도: 1.3268 (rough estimate)

굴절률: 1.6500 (estimate)

저장 조건: 2-8°C

용해도: 메탄올: 62.5mg/mL

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 2.77±0.70(Predicted)

색상: 하얀색

Merck: 14,6551

안정성: 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.

InChIKey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N

CAS 데이터베이스: 66085-59-4(CAS DataBase Reference)

NIST: Nimodipine(66085-59-4)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	20/21/22-48/22
안전지침서	36
WGK 독일	1
RTECS 번호	US7975500
위험 등급	IRRITANT
HS 번호	29333990
독성	LD50 in mice, rats (mg/kg): 3562, 6599 orally; 33, 16 i.v. (Schlüter)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P270	이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312	삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P501	...에 내용물 / 용기를 폐기 하시오.

NFPA 704

	0
1		0

Nimodipine MSDS

Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

Nimodipine C화학적 특성, 용도, 생산

개요

Nimodipine is a cerebral vasodilating calcium antagonist related to nifedipine. It is indicated for the prophylaxis and treatment of neurological deficits due to cerebral vasospasm after subarachnoid hemorrhage.

화학적 성질

Crystalline Solid

용도

Nimodipine has been used:

as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
in the pharmacological studies for the measurement of spine voltage escape

정의

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.

일반 설명

Nimodipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)- 3,5-pyridinedicarboxylic acid 2-methoxyethyl1-methylethyl ester (Nimotop), is another dihydropyridinecalcium channel blocker but differs in that it dilatesthe cerebral blood vessels more effectively than do the otherdihydropyridine derivatives. This drug is indicated for treatmentof subarachnoid hemorrhage-associated neurologicaldeficits.

생물학적 활성

L-type Ca 2+ channel blocker.

Nimodipine 준비 용품 및 원자재

원자재

Isopropyl acetoacetate (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER 에틸알코올 2-메톡시 에탄올 3-Nitrobenzaldehyde 크로톤산 2-Methoxyethyl acetoacetate 암모니아수

준비 용품

NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS)

Nimodipine 공급 업체

글로벌( 406)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
airuikechemical co., ltd.	+undefined86-15315557071	sales05@airuikechemical.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58

Nimodipine 관련 검색:

NIFE디솔 이피엔 Nitrendipine Nisoldipine Nimodipine Impurity 5 NIMODIPINE RELATED COMPOUND B (50 MG) (BIS(2-METHOXYETHYL) 2,6-DIMETHYL-4-(3-NITROPHE-NYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE) (AS) 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid bis(1-methylethyl) ester Amlodipine 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester Nimodipine DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE 3-Phenylglutaric acid Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Ethyl 3-(ethylamino)crotonate Diethyl2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate dimethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate M-NIFEDIPINE 3-(3-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER