Hydroxyzine is an antihistamine drug with M-cholinoblocking properties and expressed
action on the CNS. It suppresses subcortical regions of the CNS including the limbic system
and reticular formation. It potentiates the effect of narcotic analgesics and exhibits
sedative effects.
화학적 성질
Yellow Oil
용도
Hydroxyzine is intended for the symptomatic treatment of anxiety and stress associated
with neurosis as well as with conditions of organic illness. This drug has muscle relaxant,
antihistimine, analgesic, local anesthetic, and antiemetic action as well as a wide therapeutic effect. It is mainly used in premedication and following general anesthesia, during
which it potentiates the action of meperidine and barbiturates. It is frequently used in pediatrics as a mild sedative drug.
Indications
Drugs of choice for the treatment of dermatographism and cholinergic
urticaria. They are also effective alone or in combination with other antihistamines
in the management of acute and chronic urticaria, atopic and contact
dermatoses, and histamine-induced pruritus. It may be used alone or with other antihistamines, and dosage
should be pushed to the limit of tolerance or to subsidence of symptoms.
정의
ChEBI: A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Safety Profile
Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion. Experimental teratogenic and reproductive effects. When heated to
decomposition it emits very toxic fumes of
Cland NOx.
