하이드로코돈
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하이드로코돈 속성
- 녹는점
- 194-197°C
- 끓는 점
- 440.69°C (rough estimate)
- 밀도
- 1.1613 (rough estimate)
- 굴절률
- 1.5500 (estimate)
- 인화점
- 9℃
- 저장 조건
- Controlled Substance, -20°C Freezer
- 용해도
- 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
- 용해도
- 클로로포름(약간), 에틸아세테이트(약간), 메탄올(약간)에 용해됨
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- pKa 6.61(50% aq EtOH) (Uncertain)
- 색상
- 에탄올로부터 결정화하여 얻은 각형 결정
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 11-23/24/25-39/23/24/25 | ||
| 안전지침서 | 16-36/37-45 | ||
| 유엔번호(UN No.) | 1544 | ||
| WGK 독일 | 1 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 2939110000 | ||
| 유해 물질 데이터 | 125-29-1(Hazardous Substances Data) | ||
| 독성 | LD50 s.c. in mice: 85.7 mg/kg (Eddy, Reid) |
하이드로코돈 C화학적 특성, 용도, 생산
화학적 성질
Beige Solid용도
Hydrocodone is a powerful anticough drug that is widely used for suppressing the cough reflex. It is widely used in effective commercial anticough drugs in combination with guaiphenesin (entuss), with homatropine (hycodan), with phenylpropanolamine (hycomine), phenyltoloxamine (tussionex), and pseudoephedrine and guaiphenesin (tussened).정의
ChEBI: A morphinane-like compound that is a semi-synthetic opioid synthesized from codeine.일반 설명
Hydrocodone is the 3 methoxy version of hydromorphone.The loss of the 3-OH group yields a compound that is approximately4 to 5 times less potent than hydromorphone, thusabout equal to morphine. Unlike codeine, the agonist activityof hydrocodone does not require 3-O-demethylation, althoughit does occur via CYP2D6 representing 4.6% of totalclearance. The protected 3-position has better brain penetration,and the 7,8-dihydro-6-keto C ring contributes to the increasedbinding of the compound to the μ-receptor.There are no pure hydrocodone products available on theU.S. market. All FDA-approved products containing hydrocodoneare combination products. Like codeine, hydrocodoneis marketed as an antitussive agent. It is availablecombined with the anticholinergic agent homatropineas a syrup and a tablet. The addition of the anticholinergicagent is to discourage abuse. It is also available in a delayedrelease suspension form (Tussionex). This formulation usesa sulfonated styrene divinylbenzene copolymer complexedwith hydromorphone and chlorpheniramine that acts as acation-exchange resin slowly releasing the drugs over a 12-hour period. Hydrocodone is also marketed in combinationwith acetaminophen (Vicodin, Lortab) or aspirin (LortabASA) for the treatment of pain. The dose of acetaminophenconsumed by the patient must be closely monitored, andprescriptions that allow for greater than 4 grams of acetaminophenper 24-hour period should not be dispensed.
Safety Profile
Poison by intravenous and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.하이드로코돈 준비 용품 및 원자재
원자재
황산
코데인
Palladium hydroxide
모르핀 황산염
코디논
Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, cyclic 1,2-ethanediyl acetal, (5α)-
(5alpha)-6,7-didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
준비 용품
하이드로코돈 관련 검색:
4-아미노페놀
HYDROCODONE
HYDROCODONE BITARTRATE
Conorfone
CODEINE
HYDROCODONE FOR PEAK IDENTIFICATION - * NARC
HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATEIMP. H (EP): DIPHENYLMETHANONE(BENZOPHENONE)
HYDROCODONE-N-METHYL-D3,HYDROCODONE-D3,hydrocodone-d3solution,hydrocodone-n-methyl-d3solution
HYDROCODONE-D6
HYDROCODONE HYDROCHLORIDE
HYDROMORPHONE-3BETA-D-GLUCURONIDE
HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE - * NARC
HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATEIMP. E (EP): 7,8-DIDEHYDRO-4,5A-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6-ONE (CODEINONE)
HYDROCODONE TARTRATE 2.5 HYDRATE
Hydrocodone phosphate
HYDROCODONE BITARTRATE RELATED COMPOUND A CII (70 MG) (MORPHINAN-6-ONE, 4-HYDROXY-3-METHOXY-17-METHYL)
HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATEIMP. C (EP) AS PHOSPHATE HEMIHYDRATE:CODEINE PHOSPHATE HEMIHYDRATE[CONTROLLED SUBSTANCE]
CODEINONE