Eplerenone
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Eplerenone 속성
- 녹는점
- 241-243°C
- 알파
- D +5° (c = 0.437 in chloroform)
- 끓는 점
- 597.9±50.0 °C(Predicted)
- 밀도
- 1.31±0.1 g/cm3(Predicted)
- 저장 조건
- Store at RT
- 용해도
- DMSO: 용해성2mg/mL, 투명(가온)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- 최대 파장(λmax)
- 240nm(lit.)
- Merck
- 14,3625
- InChIKey
- UZZAHAKTLYRDOK-MGIDJNSKSA-N
- SMILES
- [C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r|
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 유엔번호(UN No.) | 3077 | ||
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| WGK 독일 | 3 | ||
| HS 번호 | 29322090 | ||
| 유해 물질 데이터 | 107724-20-9(Hazardous Substances Data) |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Eplerenone C화학적 특성, 용도, 생산
개요
Eplerenone is a mineralocorticoid receptor antagonist. It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC50s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced mineralocorticoid activity in a luciferase assay (IC50 = 122 nM). In vivo, eplerenone (100 mg/kg per day) reduces urinary albumin secretion and glomerulosclerosis in the Dahl salt-sensitive rat model of hypertension and nephropathy. It reduces myocardial IL-1β levels and collagen deposition, as well as improves left ventricular systolic dysfunction in a mouse model of acute myocardial infarction. Formulations containing eplerenone have been used in the treatment of hypertension and heart failure after myocardial infarction.화학적 성질
White Solid용도
Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.일반 설명
Eplerenone, 9,11α-epoxy-17α-hydroxy-3-oxopregn-4-ene-7α,21-dicarboxylic acid, γ-lactone,methyl ester (Inspra), is a newer aldosterone antagonist that isused for the treatment of hypertension.생물학적 활성
Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .Clinical Use
A newer drug, eplerenone, has a structure similar to that of spironolactone and a similar mechanism of action. It was initially approved for use in the treatment of hypertension but it can now be used in the treatment of patients with left ventricular systolic dysfunction and congestive heart failure after myocardial infarction.Eplerenone 준비 용품 및 원자재
원자재
준비 용품
Eplerenone 공급 업체
글로벌( 515)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Kangcang new material Technology Co., LTD | +8615713292910 |
Nancy@kangcang.com.cn | China | 341 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
| Hebei Dangtong Import and export Co LTD | +8615632927689 |
admin@hbdangtong.com | China | 984 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 |
sales@chembj.net | China | 270 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15956 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |