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BENPROPERINE

BENPROPERINE 구조식 이미지

카스 번호:: 2156-27-6

상품명:: BENPROPERINE

동의어(영문):: pirexyl;Benproperin;BRN 1258822;BRN-1258822;BENPROPERINE;Bemproperina;Benproperinum;Benproperine Monomer;BENPROPERINE USP/EP/BP;1-(2-Benzylphenoxy)-2-piperidinopropane

CBNumber:: CB4187277

분자식:: C21H27NO

포뮬러 무게:: 309.45

MOL 파일:: 2156-27-6.mol

속성

안전

용도

공급 업체 34

BENPROPERINE 속성

끓는 점: bp0.2 159-161°

밀도: 1.0350 (rough estimate)

굴절률: 1.5614 (estimate)

용해도: DMSO:1.0(Max Conc. mg/mL);3.23(Max Conc. mM)
PBS (pH:7.2):1.0(Max Conc. mg/mL);3.23(Max Conc. mM)

산도 계수 (pKa): 9.46±0.50(Predicted)

안전

독성	LD50 orally in mice: 1087 mg/kg (Tellini, De Fina)

BENPROPERINE C화학적 특성, 용도, 생산

Originator

Tussafug,Medipharm,Switz.

Manufacturing Process

A mixture of 26.1 g of o-benzylphenoxy-β-chloropropane and 17 g of piperidine is refluxed over a period of 32 hours until the temperature is about 124°C and a nearly solid mixture is formed due to the precipitation of a salt. The mixture is then refluxed over a period of 48 hours at about 160°C and the reaction product obtained is cooled and dissolved in methanol. The solution is concentrated under reduced pressure to yield an oil which is added to 200 ml 3N hydrochloric acid whereupon the mixture is shaken with ether, 3 x 100 ml, until the aqueous phase is clear. The ether solution is washed with water, 3 x 50 ml, and the water present in the combined aqueous phase and water used for washing is evaporated under reduced pressure methanol being added three times when the residue appears to be dry. The impure hydrochloride of o-benzylphenoxy-β-N-piperidinopropane, 41 g, obtained is dissolved in 100 ml water and 100 ml 30% aqueous sodium hydroxide solution are added, whereupon precipitated oil is extracted with ether, 1 x 100 and 2 x 50 ml. The ether solution is washed with water, 4 x 50 ml, dried with magnesium sulfate and the ether is removed under reduced pressure. The residue, 25.2 g, is distilled under reduced pressure and the main fraction, 23.2 g, BP 159°-161°C/0.2 mm.

Therapeutic Function

Antitussive

BENPROPERINE 준비 용품 및 원자재

원자재

파라-톨루엔설폰일 염화물 피페리딘

준비 용품

BENPROPERINE 공급 업체

글로벌( 34)공급 업체

공급자	전화	이메일	국가	제품 수	이점
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39916	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	2104	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34571	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27644	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52861	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50000	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58

BENPROPERINE 관련 검색:

S-Carboxymethyl-L-cysteine (S)-Benproperine (R)-Benproperine,R-benproperine benproperine embonate BENPROPERINE PHOSPHATE,BENPROPERINE PHOSPHATE CP2000 phenyltoloxamine HYDROQUINIDINE (ANTHRAQUINONE-1,4-DIYL) DIETHER HYDROQUININE (ANTHRAQUINONE-1 4-DIYL) BENPROPERINE 1-(2-METHYLPHENOXY)-2-PROPANAMINE Etoloxamine