(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride 구조식 이미지
카스 번호:
101152-94-7
상품명:
(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
동의어(영문):
IXEL;F 2207;Dalcipran;TOLEDOMIN;cis-(+-)-d;MIDALCIPRAN;Milnacipran HCI;MILNACIPRAN HCL;Chiral Reagents;Milnacipran HCl (1)
CBNumber:
CB4423243
분자식:
C15H23ClN2O
포뮬러 무게:
282.81
MOL 파일:
101152-94-7.mol
MSDS 파일:
SDS

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride 속성

녹는점
179-1810C
인화점
9℃
저장 조건
2-8°C
용해도
H2O: 19 mg/mL
물리적 상태
고체
물리적 상태
단단한 모양
색상
하얀색
Merck
14,6194
CAS 데이터베이스
101152-94-7(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T,F
위험 카페고리 넘버 22-39/23/24/25-23/24/25-11
안전지침서 7-16-36/37-45
유엔번호(UN No.) UN 2811 6.1/PG 3
WGK 독일 3
RTECS 번호 GZ1014010
위험 등급 6.1
포장분류 III
HS 번호 29242990
독성 LD50 orally in mice: 237 mg/kg (Bonnaud)
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
2 0

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride C화학적 특성, 용도, 생산

화학적 성질

Crystalline Solid

용도

Antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia.

일반 설명

Milnacipran, sold under the brand names Savella?, Ixel?, Dalcipran?, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin.

생물학적 활성

Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo .

(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride 준비 용품 및 원자재

원자재

준비 용품


(1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride 공급 업체

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