판크레아틴
|
|
판크레아틴 속성
- 밀도
- 1.4-1.52
- 증기압
- 0Pa at 25℃
- 저장 조건
- -20°C
- 용해도
- 약간 탁한 용액을 형성하는 물에 용해되거나 부분적으로 용해됩니다. 에탄올(96%)과 에테르에는 거의 녹지 않습니다.
- 물리적 상태
- 가루
- 색상
- 베이지색
- 수용성
- 물에 용해됩니다. 알코올과 에테르에 용해되지 않습니다.
- Merck
- 13,7075
- 안정성
- 안정적인. 알코올, 강산과 호환되지 않습니다.
- LogP
- -1.3 at 20℃ and pH5.7-5.8
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38-42-42/43 | ||
| 안전지침서 | 22-24-26-36/37-37/39 | ||
| WGK 독일 | 1 | ||
| RTECS 번호 | RT9033000 | ||
| F 고인화성물질 | 3-10 | ||
| TSCA | Yes | ||
| HS 번호 | 35079090 | ||
| 유해 물질 데이터 | 8049-47-6(Hazardous Substances Data) | ||
| 독성 | LD50 orl-rat: >10 g/kg YACHDS 3,2427,75 | ||
| 기존화학 물질 | KE-27762 |
판크레아틴 C화학적 특성, 용도, 생산
순도시험
(1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.
(3) 대장균군 : 이 품목은 「식품의 기준 및 규격」 일반시험법의 미생물시험법 중 대장균군에 따라 시험할 때, 제품 1g당 30 이하이어야 한다.
(4) 살모넬라 : 이 품목은 「식품의 기준 및 규격」 일반시험법의 미생물시험법 중 살모넬라균시험법에 따라 시험할 때, 음성(-)이어야 한다.
(5) 대장균 : 이 품목은 「식품의 기준 및 규격」일반시험법의 미생물시험법 중 대장균에 따라 시험할 때, 음성(-)이어야 한다.
확인시험
이 품목의 활성시험법에 따라 시험할 때 활성을 나타내어야 한다.
정의
이 품목은 소나 돼지의 췌장을 물로 추출하여 얻어진 것으로서 전분분해력, 지방분해력 및 단백질분해력이 있는 효소제이다. 다만, 역가조정, 품질보존 등을 위하여 희석제, 안정제 등을 첨가할 수 있다.
이 품목은 단백질을 가수분해하여 펩타이드 등을 생성하고, 전분과 지방도 가수분해한다.
화학적 성질
Pancreatin is a yellowish to cream-colored, amorphous powder with a strong odor. Slightly soluble in water. Hazard Identification (based on NFPA-704 M Rating System): Health 1, Flammability 1, Reactivity 0. Sparingly soluble in water.역사
The first observations and experimental demonstrations that pancreatin could be used to improve protein and fat digestion in animals and human patients are from the 19th century, soon after Claude Bernard had revealed the essential role of pancreatic secretion in the digestion of foods. In 1859, the dutch physician Joseph Alexander Fles showed that the daily intake of calf pancreas extract could restore the digestion of fat in a diabetic patient who suffered from diarrhea and had large amounts of fat in the stools. In 1890, Abelmann showed that the consumption of fresh pig pancreas could improve protein and fat digestion in dogs after surgical removal of the pancreas. This is considered as the first experimental demonstration of enzyme replacement[1].용도
Hydrolyzes starch into dextrins and sugar Pancreatin from porcine pancreas is used in the treatment of steatorrhea by lipase supplementation therapy and for pancreatic diabetes. It is also used in the removal of formalin-fixed tissues from arterial grafts without causing damage in fiber integrity. Further, it finds uses in contact lenses. In addition to this, it hydrolyzes starch into dextrins and sugar. It is also used to treat conditions responsible for deficiency in pancreatic secretions, such as surgical pancreatectomy, pancreatitis and cystic fibrosis.Biological Functions
Pancreatin is a supplement that can result in decreased food intake. It is used for digestion, and absorption of food. Your pancreas secretes about one and one half quarts of pancreatic juice daily into the small intestine.일반 설명
Pancreatin (Panteric) is a substance obtained from the fresh pancreas of the hog or the ox and contains a mixture of enzymes, principally pancreatic amylase (amylopsin), protease, and pancreatic lipase (steapsin). It converts not less than 25 times its weight of USP Potato Starch Reference Standard into soluble carbohydrates and not less than 25 times its weight of casein into proteoses. It acts best in neutral or faintly alkaline media, and excessive acid or alkali renders it inert. Pancreatin can be prepared by extracting the fresh gland with 25% alcohol or with water and subsequently precipitating with alcohol. Besides the enzymes mentioned, it contains some trypsinogen, which can be activated by intestinal enterokinase; chymotrypsinogen, which is converted by trypsin to chymotrypsin; and carboxypeptidase.Pancreatin is used largely for predigestion of food and for the preparation of hydrolysates. The value of its enzymes orally must be very small because they are digested by pepsin and acid in the stomach, although some of them may escape into the intestines without change. Even if they are protected by enteric coatings, it is doubtful they could be of great assistance in digestion.
Safety Profile
Moderately toxic by subcutaneous and intraperitoneal routes.잠재적 노출
It is an enzyme found in the pancreas and is used in medicines and in treating leather and textiles.비 호환성
Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols.판크레아틴 준비 용품 및 원자재
원자재
준비 용품
판크레아틴 공급 업체
글로벌( 442)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CHONGQING QUANXINXIANGSHENG BIO PHARMACEUTICAL CO LTD | +86-18983081620 +86-18983081620 |
sales@qxxsbiopharm.com | China | 2 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12468 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 985 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 |
sales05@airuikechemical.com | China | 994 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1142 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 2525 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 783 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |