P-크레졸

P-크레졸 속성

P-크레졸 MSDS

4-Methylphenol

P-크레졸 C화학적 특성, 용도, 생산

물성

무색 황색을 띠는 투명한 액체.

용도

P- 크레졸,흰색 또는 무색 결정. 알코올에 용해, 에테르, 클로로포름 및 온수에. 주요 용도: 의학, 살충제, 향수, 합성 수지 및 염료, 등.

화학적 성질

Cresol is a mixture of three isomeric forms: o-, m-, and p-cresol. These compounds are slightly soluble in water. The m-isomer is a colorless or yellow liquid with characteristic odor. The p-cresol is a colorless to pink crystals with a characteristics phenol-like odor. The concentration at which the odor becomes detectable in water is 55 parts per billion (Buttery et al., 1988). Another study by Leonardos et al. (1969) reported an experimental odor threshold concentration of 1 parts per billion, which is higher than the 0.054 parts per billion reported by Nagata and Takeuchi (1990).

출처

Has been found in a score of essential oils including ylang ylang and oil of jasmine (Gildemeister & Hoffman, 1966).

용도

p-Cresol is utilized in the production of artificial resins, liquid crystal intermediates, disinfectants, fumigants, and as an industrial solvent. It is also involved in the manufacturing of Bupranolol, a non-selective beta blocker.

정의

ChEBI: P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, a human metabolite and an Escherichia coli metabolite.

생산 방법

The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. p-Cresol is a 4-methyl derivative of phenol and is prepared from m-toluic acid or obtained from coal tar or petroleum. Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ～180–201°C. p-Cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluene or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.

제조 방법

It can be prepared by fractional distillation of coal tar where it occurs together with the ortho- and para- isomers.

일반 설명

Colorless solid with a tar like odor. Sinks and mixes slowly with water.

공기와 물의 반응

Insoluble in water.

반응 프로필

p-Cresol is sensitive to heat. p-Cresol is also sensitive to light. p-Cresol is incompatible with strong oxidizers and strong alkalis. p-Cresol will attack some forms of plastics, coatings and rubber.

건강위험

INHALATION: Irritation of nose or throat. EYES: Intense irritation and pain, swelling of conjunctiva and corneal damage may occur. SKIN: Intense burning, loss of feeling, white discoloration and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Absorption by all routes may cause muscular weakness, gastroenteric disturbance, severe depression and collapse. Effects are primarily on central nervous system, edema of lungs, injury of spleen and pancreas may occur.

Safety Profile

Poison by ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. A severe skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data by itself and with 7,12-dirnethyl benz(a)anthracene. Combustible when exposed to heat or flame. Moderately explosive in the form ofvapor when exposed to heat or flame. To fight fire, use CO2, dry chemical, alcohol foam. See also other cresol entries and PHENOL.

잠재적 노출

Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.

Carcinogenicity

o-Cresol has been induced a few papillomas but no carcinomas in tumor studies.

신진 대사

p-Cresol is oxidized at the methyl group in both dogs and rabbits to yield ρ-hydroxybenzoic acid. In the rabbit up to 10% of oral doses of 0.25-0.5 g is excreted as free and conjugated p-hydroxybenzoic acid (Williams, 1959).

운송 방법

UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.

Purification Methods

It can be separated from m-cresol by fractional crystalisation of its melt. Purify it by distillation, by precipitation from *benzene solution with pet ether, and via its benzoate, as for phenol. Dry it under vacuum over P2O5. It has also been crystallised from pet ether (b 40-60o) and by conversion to sodium p-cresoxyacetate which, after crystallisation from water is decomposed by heating with HCl in an autoclave [Savard Ann Chim (Paris) 11 287 1929]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 189o. [Beilstein 6 II 2093.]

비 호환성

Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.

폐기물 처리

Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.

P-크레졸 준비 용품 및 원자재

원자재

준비 용품

P-크레졸 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503259 +86-19930503259	cherry@crovellbio.com	China	18449	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12468	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2966	58

P-크레졸 관련 검색: