Calcium dobesilate
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Calcium dobesilate 속성
- 녹는점
- >300° (dec)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- H2O: 용해성15mg/mL, 투명
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- 안정성
- 흡습성
- InChIKey
- QGNBTYAQAPLTMX-UHFFFAOYSA-L
- CAS 데이터베이스
- 20123-80-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | IRRITANT | ||
| 독성 | LD50 in mice: 700 mg/kg (Esteve-Subirana) |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Calcium dobesilate C화학적 특성, 용도, 생산
개요
Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.
화학적 성질
White or almost white, hygroscopic powder.용도
Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.Indications
Calcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).
일반 설명
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.부작용
FeverSkin reactions
Arthralgia(joint pain)
Gastrointestinal disorders
Agranulocytosis (lower white blood cell count)
Calcium dobesilate 준비 용품 및 원자재
원자재
준비 용품
Calcium dobesilate 공급 업체
글로벌( 346)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 |
daisy@crovellbio.com | China | 5957 | 58 |
| XuZhou Magic Biotechnology Co., Ltd. | +undefined13921770081 |
SVP01@magicbiotech.cn | China | 92 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 3002 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 |
sales01@airuikechemical.com | China | 994 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 2603 | 58 |
| Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 |
clara@hbshengyang.com | China | 783 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Zjartschem | +86-571-8723 8903 jocelynpan@zjarts.com |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |