2,4,6,8-테트라히드록시-피리미도-(5,4D)피리미딘
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2,4,6,8-테트라히드록시-피리미도-(5,4D)피리미딘 속성
- 밀도
- 1.89±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 5.90±0.20(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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| 예방조치문구: |
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2,4,6,8-테트라히드록시-피리미도-(5,4D)피리미딘 C화학적 특성, 용도, 생산
용도
2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops.Synthesis
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.
2,4,6,8-테트라히드록시-피리미도-(5,4D)피리미딘 준비 용품 및 원자재
원자재
준비 용품
2,4,6,8-테트라히드록시-피리미도-(5,4D)피리미딘 공급 업체
글로벌( 119)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 |
stella@zetchem.com | China | 2141 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14336 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 |
mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
2,4,6,8-테트라히드록시-피리미도-(5,4D)피리미딘 관련 검색:
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
Dipyridamole Mono-O-b-D-glucuronide
Dipyridamole
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE
2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
2,2',2'',2'''-[[4-[(2-Hydroxyethyl)aMino]-8-(1-piperidinyl)pyriMido[5,4-d]pyriMidine-2,6-diyl]dinitrilo]tetrakisethanol
(DipyridaMole IMpurity)
Dipyridamole Tripiperidine
Dipyridamole Tri(diethanolamine)
6-Des(diethanolamino)-6-chloro Dipyridamole
4,8-dichloro-2,6-dipiperidinopyrimido[5,4-d]pyrimidine
Desethanol Dipyridamole
Pyrimido[5,4-d]pyrimidin-4-ol (8CI)
2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine