팔레칼시트리올
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팔레칼시트리올 속성
- 끓는 점
- 576.9±50.0 °C(Predicted)
- 밀도
- 1.24±0.1 g/cm3(Predicted)
- 저장 조건
- Store at -20°C,unstable in solution, ready to use.
- 용해도
- DMSO에 용해됨
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.77±0.29(Predicted)
안전
팔레칼시트리올 C화학적 특성, 용도, 생산
개요
Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.용도
Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.위험도
A poison by ingestion.팔레칼시트리올 준비 용품 및 원자재
원자재
준비 용품
팔레칼시트리올 공급 업체
글로벌( 89)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 |
sales@dolonchem.com | CHINA | 2972 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 |
mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| CR Corporation Lomited | |
fred.wen@crcorporation.cn | CHINA | 12069 | 58 |
| ChemExpress | +86-021-58950125 |
info@chemexpress.com | China | 566 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 |
sales@tnjchem.com | China | 25363 | 58 |
팔레칼시트리올 관련 검색:
5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester
methylene calcitriol
INECALCITOL
Calcitriol
(S)-(-)-1,1,1-TRIFLUOROOCTAN-2-OL
FALECALCITRIOL
VitaMin D4
CALCIFEDIOL
Calcifediol Monohydrate
(S)-(-)-1,1,1-TRIFLUOROHEPTAN-2-OL
1,2-DIMETHYLENE-CYCLOHEXANE
(S)-(-)-1,1,1-TRIFLUORODECAN-2-OL
(R)-(+)-1 1 1-TRIFLUOROOCTAN-2-OL 97
(S)-(-)-1,1,1-TRIFLUORODODECAN-2-OL
1,1,1-TRIFLUORO-2-OCTANOL
(S)-(-)-1,1,1-TRIFLUORONONAN-2-OL
(S)-(-)-1,1,1-TRIFLUOROUNDECAN-2-OL
(R)-(+)-1-FLUORO-2-OCTANOL