Dimethoxanate

Dimethoxanate C화학적 특성, 용도, 생산

Originator

Cothera,Ayerst,US,1957

Manufacturing Process

5.23 g of phenothiazine-10-carboxylic acid chloride were suspended in 8 g of dimethylaminoethoxyethanol and heated, with stirring, under anhydrous conditions, first for 1 hour at a temperature of 50°-105°C, then for another hour at 108°-110°C. All the suspended acid chloride had dissolved after the final heating, and the solution was then allowed to cool slowly to 75°C over a period of one hour. Infrared examination of a sample showed that the esterification reaction was essentially complete after the second hour
The reaction mixture was then poured on 1 liter of crushed ice, and the oily precipitate washed repeatedly by decantation with ice water. It was then taken up in 75 ml of benzene, and again washed repeatedly with water until a pH of 8.2 in the washings indicated that substantially all of the excess β- dimethylaminoethoxyethanol had been removed. The benzene solution was then dried with anhydrous sodium sulfate, filtered, and the benzene evaporated in a current of dry nitrogen gas. The residual dark oil constituted the desired basic ester. β-Dimethylaminoethoxyethyl phenothiazine-10- carboxylate.
The basic ester may be dissolved in anhydrous ether and then precipitated by adding a slight excess of a solution of dry hydrogen chloride in ether and the hydrochloride salt may be isolated as an amorphous, glasslike product, which could be crystallized from anhydrous acetone or from methanol-ether. In this manner there was obtained as a stable, crystalline, colorless substance β- dimethylaminoethoxyethyl phenothiazine-10-carboxylate hydrochloride, one sample of which melted at 161°-163°C with decomposition.

Therapeutic Function

Antitussive

Dimethoxanate 준비 용품 및 원자재

원자재

준비 용품

Dimethoxanate 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	2357	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	27945	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	50002	58
Wuhan pengyin Pharmaceutical Co., Ltd	13163333255	1939328613@qq.com	China	395	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	17691182729 18161915376	1046@dideu.com	China	10011	58

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