Tolmetin manufacturers and suppliers

Tolmetin suppliers

Properties

Melting point:: 156 °C

Boiling point:: 400.53°C (rough estimate)

Density: 1.1391 (rough estimate)

refractive index: 1.5200 (estimate)

storage temp.: 2-8°C

solubility: Chloroform (Slightly), Methanol (Slightly)

pka: pKa 3.5(H2O t undefined I undefined) (Uncertain)

form: Solid

color: Off-White to Pale Yellow

Water Solubility: 222 mg/L

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H302-H335-H319

Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

Use

Tolmetin sodium (Tolectin), is an arylacetic acid derivativewith a pyrrole as the aryl group. This drug is well absorbed and has a relatively short plasma half-life (1 hour). It is recommendedfor use in the management of acute and chronicRA. Its efficacy is similar to aspirin and indomethacin, butwith less frequency of the adverse effects and tinnitus associatedwith aspirin. It does not potentiate coumarin-likedrugs nor alter the blood levels of sulfonylureas or insulin.However, tolmetin, and especially its closely related drug,zomepirac (i.e., with a p-chlorobenzoyl group and an additionalmethyl group on the pyrrole ring), can produce a rarebut fatal anaphylactic reaction because of irreversible bindingof their unstable acyl glucuronides. Zomepirac waswithdrawn from market because it is eliminated only via theester-type, acyl glucuronide. It is possible that tolmetin isless toxic in this regard because it undergoes additional hepaticbenzylic hydroxylation via its p-methyl group and isexcreted as its stable ether glucuronide.

You can find Tolmetin suppliers, manufacturers, and distributors from countries such as China, United States and the Germany here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.