GHRELIN (HUMAN)

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Company Name: Cellmano Biotech Limited
Tel: 0551-65326643 18156095617
Email: info@cellmano.com
Products Intro: Product Name:Ghrelin (human)
CAS:258279-04-8
Company Name: Hebei Runbin Biotechnology Co. LTD
Tel: 13180553332
Email: 2179877681@qq.com
Products Intro: Product Name:Ghrelin
CAS:258279-04-8
Purity:99% Package:1KG;15USD
Company Name: BOC Sciences
Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:Ghrelin (human)
CAS:258279-04-8
Remarks:BOC Sciences also provides custom synthesis services for Ghrelin (human).
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: CAS:258279-04-8
Purity:99% Package:5KG;1KG
Company Name: Hangzhou Go Top Peptide Biotech
Tel: 0571-88211921
Email: sales1@gotopbio.com
Products Intro: Product Name:Ghrelin(human)
CAS:258279-04-8
Purity:98% HPLC、MS Package:1mg/ plastic bottle ,customer's requirement packaging also welcome
GHRELIN (HUMAN) Basic information
Product Name:GHRELIN (HUMAN)
Synonyms:H-GLY-SER-SER(OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;H-GLY-SER-[SER(N-OCTANOYL)]-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GHRELIN (HUMAN);GHRELIN (HUMAN) TRIFLUOROACETATE;GHRELIN TRIFLUOROACETATE SALT;GS-S(N-OCTANOYL)-FLSPEHQRVQQRKESKKPPAKLQPR
CAS:258279-04-8
MF:C149H249N47O42
MW:3370.86
EINECS:
Product Categories:Cytokine;Peptide Receptors;Peptide;Ghrelin receptor
Mol File:258279-04-8.mol
GHRELIN (HUMAN) Structure
GHRELIN (HUMAN) Chemical Properties
density 1.49±0.1 g/cm3(Predicted)
storage temp. -15°C
solubility Soluble in H2O
form Solid
Water Solubility Soluble in water, and 5% acetic acid.
Safety Information
HS Code 2933299090
MSDS Information
GHRELIN (HUMAN) Usage And Synthesis
UsesGhrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. It is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.
UsesThe GHS-R (growth hormone secretagogue receptor) potently stimulates growth hormone release from the pituitary gland in vivo and in vitro. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Ghrelin (human) is an activator of GHS-R1a.
Biological Activityghrelin is a specific endogenous ligand for the ghs receptor which can stimulate strong increase in circulating gh levels both in vitro and in vivo in a dose-dependent manner, human acylated ghrelin is the major active form that can cross the blood-brain barrier, and has an effection on the activity of arcute neurones with a much stronger affinity (ic50, 0.3×10-9m) than ghsr antagonist (d-lys3)-ghrp-6 (ic50, 0.9×10-6m)[1].ghrelin has effects in stimulating appetite, increasing secretion of gh and hypo-catabolism, improvement of gastrointestinal motility, increasing cardiac output, improvement of pulmonary function and anti-inflammatory effect.clinical applications of ghrelin in total gastrectomy, esophagectomy and neoadjuvant chemotherapy can stimulate food intake, improve guality of life scores and minimize adverse events. recently, ghrelin as a effective approach in the management of anorexia nervosa[2],cachexia[3], bw[4] and appetite loss[5], systemic inflammatory response[6]and cancer[7]. in conclusion, ghrelin is a promising candidate for treating catabolic states and enhancing immune function in cachexia or acquired immunodeficiency syndrome, as well as for treating eating disorders such as obesity and anorexia nervosa.
storageStore at -20°C
references1. m. traebert,* t. riediger,† s. whitebread,* e. scharrer† and h. a. schmid*. ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. journal of neuroendocrinology, 2002, vol. 14, 580–5862. hotta m, ohwada r, akamizu t, shibasaki t, takano k, kangawa k. ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study. endocr j. 2009;56:1119–28.3. nagaya n, itoh t, murakami s, oya h, uematsu m, miyatake k, et al. treatment of cachexia with ghrelin in patients with copd. chest. 2005;128:1187–93.4. adachi s, takiguchi s, okada k, yamamoto k, yamasaki m, miyata h, et al. effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase ii study. gastroenterology. 2010;138:1312–20.5. hiura y, takiguchi s, yamamoto k, kurokawa y, yamasaki m, nakajima k, et al. fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients. int j clin oncol. 2012;17:316–23.6. cheyuo c, jacob a, wang p. ghrelin-mediated sympathoinhibition and suppression of inflammation in sepsis. am j physiol endocrinol metab. 2012;302:e265–72.7. yoshida n, watanabe m, baba y, iwagami s, ishimoto t, iwatsuki m, et al. risk factors for pulmonary complications after esophagectomy for esophageal cancer. surg today. 2014;44:526–32.
GHRELIN (HUMAN) Preparation Products And Raw materials
Tag:GHRELIN (HUMAN)(258279-04-8) Related Product Information
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