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OXYCODONE HYDROCHLORIDE

OXYCODONE HYDROCHLORIDE Basic information
Product Name:OXYCODONE HYDROCHLORIDE
Synonyms:OXYCODONE HYDROCHLORIDE;14-hydroxydihydrocodeinonehydrochloride;4,5-alpha-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-onhydrochloride;4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one,hydrochloride,(5-a;dihydronehydrochloride;dihydrooxycodeinonehydrochloride;(5a)-4,5-Epoxy-14-hydroxy-3-methoxy-17-methyl-morphinan-6-one Hydrochloride;Supeudol
CAS:124-90-3
MF:C18H22ClNO4
MW:351.82
EINECS:204-717-1
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:124-90-3.mol
OXYCODONE HYDROCHLORIDE Structure
OXYCODONE HYDROCHLORIDE Chemical Properties
Melting point 261-2630C
alpha D20 -125° (c = 2.5)
Fp 11℃
storage temp. 2-8°C
solubility Freely soluble in water, sparingly soluble in anhydrous ethanol, practically insoluble in toluene.
Water Solubility 142.9g/L(temperature not stated)
CAS DataBase Reference124-90-3
Safety Information
Hazard Codes Xn,T,F
Risk Statements 22-39/23/24/25-23/24/25-11
Safety Statements 36/37-45-16-7
RIDADR UN 1230 3/PG 2
WGK Germany 3
RTECS QD2470000
HazardClass 6.1(a)
PackingGroup II
HS Code 2939110000
Toxicitycat,LDLo,intravenous,2500ug/kg (2.5mg/kg),LUNGS, THORAX, OR RESPIRATION: OTHER CHANGESBEHAVIORAL: ANALGESIA,Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 194, Pg. 296, 1940.
MSDS Information
OXYCODONE HYDROCHLORIDE Usage And Synthesis
DescriptionOxycodone (hydrochloride) (Item No. 26513) is an analytical reference standard categorized as an opioid. Oxycodone is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemical PropertiesWhite Solid
OriginatorOxyfast,Purdue Pharma, L.P.
UsesControlled substance (opiate). Analgesic (narcotic)
DefinitionChEBI: Oxycodone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. It is a moderately potent opioid analgesic, generally used for relief of moderate to severe pain. It has a role as a mu-opioid receptor agonist, an antitussive and an opioid analgesic. It contains an oxycodone(1+).
Brand nameOxycontin (Purdue); Roxicodone (Roxane); Roxicodone (Xanodyne).
Therapeutic FunctionNarcotic analgesic
Biological ActivityPotent and selective μ -opioid receptor agonist (K i values are 16 and >1000 nM for hMOR1 and hKOR1 respectively).
Clinical UseOxycodone is about equipotent with morphine, but because of the 3-OCH group, it has a much lower oral:parenteral dose ratio. Thus, oxycodone is used orally to treat severe to moderate pain. It is a drug as a single agent and when combined in strong analgesic mixtures. Oxycodone has a plasma half-life of approximately 4 hours and requires dosing every 4 to 6 hours.
Drug interactionsPotentially hazardous interactions with other drugs
Analgesics: possible opioid withdrawal with buprenorphine and pentazocine.
Antibacterials: metabolism possibly increased by rifampicin; metabolism inhibited by telithromycin.
Antidepressants: CNS excitation or depression with MAOIs - avoid; possible CNS excitation or depression with moclobemide; increased sedative effects with tricyclics.
Antifungals: concentration increased by voriconazole.
Antihistamines: increased sedative effects with sedating antihistamines.
Antipsychotics: enhanced hypotensive and sedative effects.
Antivirals: concentration possibly increased by ritonavir.
Dopaminergics: avoid with selegiline.
Nalmefene: avoid concomitant use.
Sodium oxybate: enhanced effect of sodium oxybate - avoid.
MetabolismOxycodone is metabolised in the liver to produce noroxycodone via the CYP3A system, oxymorphone via the CYP2D6 system and various conjugated glucuronides.
The analgesic effects of the metabolites are clinically insignificant. Both metabolites undergo glucuronidation and are excreted with unchanged drug in urine.
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