- tipepidine USP/EP/BP
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- $1.10 / 1g
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2021-06-01
- CAS:5169-78-8
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100Tons min
- tipepidine
-
- $0.01 / 1KG
-
2020-04-25
- CAS:5169-78-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50 tons
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| tipepidine Basic information |
Product Name: | tipepidine | Synonyms: | 14698-07-8 (Citrate[1:1]);1-Methyl-3-piperidylidenedi(2-thienyl)methane;3-(Di-2-thienylmethylene)-1-methyl-piperidine;At 327;Bitiodin;Brn 0212554;Cr/662;3-(Dithien-2-ylmethylene)-1-methylpiperidine | CAS: | 5169-78-8 | MF: | C15H17NS2 | MW: | 275.43 | EINECS: | | Product Categories: | | Mol File: | 5169-78-8.mol | |
| tipepidine Chemical Properties |
Melting point | 64-65° | Boiling point | bp4-5 178-184° | density | 1.1947 (rough estimate) | refractive index | 1.5300 (estimate) | pka | 8.23±0.20(Predicted) |
Toxicity | LD50 in mice (mg/kg): 294 i.p.; 308 i.m.; 867 orally (Higaki) |
| tipepidine Usage And Synthesis |
Originator | Sotal,G. Ramon | Definition | ChEBI: Tipepidine is a member of piperidines. | Manufacturing Process | From ethyl 1-methylpiperidine-3-carboxylate (which was prepared by
hydrogenation of ethyl nicotinate with Ni-catalyst and then by methylation by
action dimethyl sulfate) and 2-thienyl magnesium bromide was synthesized
1,1-di(thiophen-2-yl)-2-(3'-N-methylpiperidine), 3-(di-2-thienylmethylene)-1-
methylpiperidine was obtained by dehydration of 1,1-di(thiophen-2-yl)-2-(3'-
N-methylpiperidine) by action of base. | Therapeutic Function | Antitussive, Expectorant |
| tipepidine Preparation Products And Raw materials |
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