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Adavivint

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Adavivint Suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:Adavivint
CAS:1467093-03-3
Purity:98% grace@coreychem.com Package:1KG;3.07USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:Adavivint
CAS:1467093-03-3
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Adavivint (SM04690)
CAS:1467093-03-3
Purity:98% Package:5mg Remarks:V4124
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:Adavivint；Adavivint (SM04690)
CAS:1467093-03-3
Package:1 mg；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:Adavivint
CAS:1467093-03-3
Purity:97%+ Package:10mg,500mg,1g,5g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Adavivint Basic information
Product Name:Adavivint
Synonyms:N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide;SM-04690;SM 04690;SM04690;Butanamide, N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methyl-;SM04690;CPD1633;Adavivint;Wnt,SM 04690,Adavivint,SM04690,Lorecivivint,SM-04690,inhibit,Inhibitor;Lorecivivint
CAS:1467093-03-3
MF:C29H24FN7O
MW:505.55
EINECS:
Product Categories:
Mol File:1467093-03-3.mol
Adavivint Structure
Adavivint Chemical Properties
density 1.365±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:27.5(Max Conc. mg/mL);54.4(Max Conc. mM)
pka7.75±0.40(Predicted)
Safety Information
MSDS Information
Adavivint Usage And Synthesis
UsesAdavivint is an intra-articular potential disease-modifying osteoarthritis drug.
Biological ActivityAdavivint (SM04690) is a potent canonical Wnt signaling pathway inhibitor with EC50 of 19.5 nM for TCF/LEF reporter gene. It was more potent than other known Wnt inhibitors in multiple cellular experiments.
in vitro

Treatment of bone marrow-derived human mesenchymal stem cells (CD29+, CD44+ CD166+ CD105+ CD45-) with SM04690 induced a concentration-dependent decrease in Wnt pathway gene expression (ASCL1, LEF1, TCF7L2, TCF7 , C-262 MYC and AXIN2). Selective activation of Wnt signaling pathway with Wnt3a or GSK3β inhibitor CHIR-99021, in IEC6 (intestinal stem cells sensitive to Wnt activation), M04690 can inhibit the expression of AXIN2 and LGR5; in hMSCs, inhibit the expression of AXIN2, TCF7 and LEF1 Express. It has minimal effects on non-canonical Wnt signaling and BMP signaling. In vitro, SM04690 protects chondrocytes from metabolic breakdown.

in vivo

Intra-articular injection of Adavivint promotes cartilage growth and improves joint health in a rat model of knee osteoarthritis. In vivo, it reduces cartilage breakdown.

target
TargetValue
Wnt
()
Adavivint Preparation Products And Raw materials
Raw materials5-(3-fluorophenyl)pyridine-3,4-diamine
Tag:Adavivint(1467093-03-3) Related Product Information
Barium carbonate 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide BAY 299 T-26c AZD-7594 4-[4-(1-methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]-benzonitrile ABBV-744 Zofluza intermediate RGX-104 HCl