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| | BAY 299 Basic information |
| Product Name: | BAY 299 | | Synonyms: | BAY-299; BAY 299; BAY299;6-(3-hydroxypropyl)-2-(1,3,6-trimethyl-2-oxobenzimidazol-5-yl)benzo[de]isoquinoline-1,3-dione;BAY 299;CPD1617;6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione;1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-;6-(3-Hydroxy-propyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-benzo[de]isoquinoline-1,3-dione | | CAS: | 2080306-23-4 | | MF: | C25H23N3O4 | | MW: | 429.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2080306-23-4.mol |  |
| | BAY 299 Chemical Properties |
| Boiling point | 688.7±55.0 °C(Predicted) | | density | 1.377±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:30.0(Max Conc. mg/mL);69.85(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);69.85(Max Conc. mM) | | form | A crystalline solid | | pka | 14.98±0.10(Predicted) |
| | BAY 299 Usage And Synthesis |
| Description | BAY-299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 (IC50 = 6 nM), also known as BRPF2, and the second bromodomain of transcription initiation factor TFIID subunits 1 (TAF1; IC50 = 13 nM). BAY-299 is >30-fold selective over BRPF1, BRPF3, BRD9, and ATAD2 and is >300-fold selective over BRD4. See the Structural Genomics Consortium (SGC) website for more information. | | Uses | BAY 299, is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1, also known as BRPF2, and a strong inhibitor of TAF1/TAF1L BD2. These proteins play important roles in transcription regulation. | | storage | Store at -20°C |
| | BAY 299 Preparation Products And Raw materials |
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