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| | PARAMETHASONE ACETATE (200 MG) Basic information |
| Product Name: | PARAMETHASONE ACETATE (200 MG) | | Synonyms: | cortidene;21-Acetoxy-6a-fluoro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione;21-Acetyl-6a-fluoro-16a-methylprednisolone;6a-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 21-acetate;6a-Fluoro-16a-methylprednisolone 21-acetate;Dillar;Flumethone;Metilar | | CAS: | 1597-82-6 | | MF: | C24H31FO6 | | MW: | 434.4977432 | | EINECS: | 2164864 | | Product Categories: | | | Mol File: | 1597-82-6.mol |  |
| | PARAMETHASONE ACETATE (200 MG) Chemical Properties |
| Melting point | 228-241° (dec) | | alpha | D +85° | | Boiling point | 584.2±50.0 °C(Predicted) | | density | 1.1517 (estimate) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.29±0.70(Predicted) | | color | Crystals from Me2CO/hexane | | EPA Substance Registry System | Paramethasone acetate (1597-82-6) |
| Toxicity | LD50 i.p. in female rats: 392±23 mg/kg (Goldenthal) |
| | PARAMETHASONE ACETATE (200 MG) Usage And Synthesis |
| Originator | Haldrone,Lilly,US,1961 | | Uses | Paramethasone Acetate, is a derivative of Dexamethasone (D298800), a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. | | Uses | Glucocorticoid. | | Definition | ChEBI: Paramethasone acetate is a corticosteroid hormone. | | Manufacturing Process | A solution of 0.144 g of the 3-ethylene glycol ketal of 5α,11β,17α,21 tetrahydroxy-6β-fluoro-16α-methylallopregnane-3,20-dione-21 acetate in 12 ml of chloroform and 0.1 ml of absolute alcohol was cooled to -10°C in an icesalt bath and a stream of anhydrous hydrochloric acid was gently bubbled through the solution for 2.5 hours while the temperature was maintained between -5°C and -15°C. The solution was then diluted with 25 ml of chloroform, washed with dilute sodium bicarbonate and water, dried over anhydrous sodium sulfate, and evaporated to dryness under reduced pressure at 60°C or less to give 6α-fluoro-11β,17α,21-trihydroxy-16α-methyl-4-pregnene3,20-dione 21-acetate. | | Brand name | Haldrone (Lilly). | | Therapeutic Function | Glucocorticoid | | Safety Profile | Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of Fí. |
| | PARAMETHASONE ACETATE (200 MG) Preparation Products And Raw materials |
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