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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyrimidines >Aminopyrimidine >4-Aminopyrazolo[3,4-d]pyrimidine

4-Aminopyrazolo[3,4-d]pyrimidine

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Company Name: Changzhou uniringchem Co., Ltd.
Tel: +undefined13585446801
Email: sales@uniringchem.com
Products Intro: Product Name:4-Aminopyrazolo[3,4-d]pyrimidine
CAS:2380-63-4
Purity:0.98 Package:500kg,100kg,5KG;1KG
Company Name: Taizhou Creating Bio-pharm co., ltd.
Tel: +8613586099526
Email: post@creatingbiopharm.com
Products Intro: Product Name:1H-Pyrazolo[3,4-d]pyrimidin-4-amine
CAS:2380-63-4
Purity:0.99 Package:1G；100G;1KG
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
Email: sales@hbmojin.com
Products Intro: Product Name:4-Aminopyrazolo[3,4-d]pyrimidine
CAS:2380-63-4
Purity:99% Package:25KG
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +86-371-86557731 +86-13613820652
Email: info@fdachem.com
Products Intro: Product Name:4-Aminopyrazolo[3,4-d]pyrimidine
CAS:2380-63-4
Purity:98% Package:1KG;5USD|1000KG;0.1USD
Company Name: Capot Chemical Co.,Ltd.
Tel: 571-85586718 +8613336195806
Email: sales@capotchem.com
Products Intro: Product Name:1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS:2380-63-4
Purity:95% (Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg

4-Aminopyrazolo[3,4-d]pyrimidine manufacturers
4-Aminopyrazolo[3,4-d]pyrimidine Basic information
Product Name:4-Aminopyrazolo[3,4-d]pyrimidine
Synonyms:TIMTEC-BB SBB004205;1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE;4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;ADENINE ANTIMETABOLITE;4- aMinopyrazolo [3,4-d] pyriMidines;PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE;4-Amino-1H-pyrazolo[3,4-d]pyrimidine,98%
CAS:2380-63-4
MF:C5H5N5
MW:135.13
EINECS:219-174-6
Product Categories:Heterocyclic Compounds;Heterocycles;PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Heterocycle-Pyrimidine series
Mol File:2380-63-4.mol
4-Aminopyrazolo[3,4-d]pyrimidine Structure
4-Aminopyrazolo[3,4-d]pyrimidine Chemical Properties
Melting point >325 °C(lit.)
Boiling point 238.81°C (rough estimate)
density 1.3795 (rough estimate)
refractive index 1.7000 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in DMSO
form powder to crystal
pka12.12±0.20(Predicted)
color White to Orange to Green
Water Solubility Insoluble in water.
BRN 5824
InChIKeyLHCPRYRLDOSKHK-UHFFFAOYSA-N
CAS DataBase Reference2380-63-4(CAS DataBase Reference)
NIST Chemistry Reference1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4)
EPA Substance Registry System1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4)
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38-23/24/25
Safety Statements 26-36/37/39-45-22-36
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UR0717000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29335990
ToxicityLD50 oral in rat: 141mg/kg
MSDS Information
ProviderLanguage
4-Aminopyrazolo[3,4-d]pyrimidine English
SigmaAldrich English
ACROS English
ALFA English
4-Aminopyrazolo[3,4-d]pyrimidine Usage And Synthesis
Description4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].
Chemical PropertiesLight Tan Solid
Uses4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.
References [1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.
4-Aminopyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials
Preparation Products(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine
Tag:4-Aminopyrazolo[3,4-d]pyrimidine(2380-63-4) Related Product Information
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