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| | Ethyl 4-aminophenylacetate Basic information |
| | Ethyl 4-aminophenylacetate Chemical Properties |
| Melting point | 48-50 °C | | Boiling point | 120-122 °C(Press: 2 Torr) | | density | 1.112±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 4.55±0.10(Predicted) | | color | White to Orange to Green | | InChI | InChI=1S/C10H13NO2/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6H,2,7,11H2,1H3 | | InChIKey | CFNDVXUTYPXOPG-UHFFFAOYSA-N | | SMILES | C1(CC(OCC)=O)=CC=C(N)C=C1 | | CAS DataBase Reference | 5438-70-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | Hazard Note | Irritant | | HS Code | 29163400 |
| | Ethyl 4-aminophenylacetate Usage And Synthesis |
| Chemical Properties | pinkish-white to beige powder | | Uses | Used as an intermediate in pharmaceutical research. | | Synthesis | A solution of (4-nitro-phenyl)-acetic acid ethyl ester (Preparation 266, 3.4 g, 16.1 mmol) in methanol (100 mL) was degassed with argon for 15 min, treated with 10% palladium on charcoal (700 mg), and then stirred at room temperature under hydrogen (balloon pressure) for 16 hours. The reaction mixture was filtered through celite, washed with methanol (2 × 20 mL) and the filtrate Ethyl 4-aminophenylacetate was evaporated in vacuo. Yield: 96%, 2.8 g, oil. 1H NMR (400 MHz, CDCl3) δ: 1.23 (t, 3H), 3.47 (s, 2H), 3.60 (br s, 2H), 4.11 (q, 2 H), 6.63 (d, 2H), 7.05 (d, 2H).
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| | Ethyl 4-aminophenylacetate Preparation Products And Raw materials |
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