- Nikethamide
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- $0.00 / 25kg
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2024-06-06
- CAS:59-26-7
- Min. Order: 1kg
- Purity: 98% HPLC
- Supply Ability: 1500 kgs
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| | N,N-DIETHYLNICOTINAMIDE Basic information |
| | N,N-DIETHYLNICOTINAMIDE Chemical Properties |
| Melting point | 23 °C (lit.) | | Boiling point | 296-300 °C (lit.) | | density | 1.06 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.524(lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | pKa 3.46(H2O,t =20) (Uncertain) | | form | Liquid | | color | Clear colorless to yellow | | Merck | 14,6543 | | BRN | 5743 | | InChI | InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3 | | InChIKey | NCYVXEGFNDZQCU-UHFFFAOYSA-N | | SMILES | C1=NC=CC=C1C(N(CC)CC)=O | | CAS DataBase Reference | 59-26-7(CAS DataBase Reference) | | EPA Substance Registry System | Nikethamide (59-26-7) |
| Hazard Codes | T | | Risk Statements | 25-36/37/38-23/24/25 | | Safety Statements | 26-45-36/37/39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | QS4375000 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29333999 | | Toxicity | LD50 i.p. in rats: 272 mg/kg (Goldenthal) |
| | N,N-DIETHYLNICOTINAMIDE Usage And Synthesis |
| Description | A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca
M. Pop. It forms colourless needles from EtOH and is optically active with a
specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p.
216-9°C and the hydrobromide, m.p. 223-6°C have been described. | | Chemical Properties | clear colorless to yellow liquid | | Uses | analeptic | | Uses | N,N-Diethylnicotinamide (DENC) is commonly used as a ligand to prepare tetranuclear copper complexes. | | Definition | ChEBI: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide. | | Application | N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX. | | General Description | Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. | | Air & Water Reactions | Water soluble. | | Reactivity Profile | N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. . | | Health Hazard | ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes. | | Fire Hazard | N,N-DIETHYLNICOTINAMIDE is combustible. | | Safety Profile | Poison by ingestion,
intravenous, intraperitoneal, and
subcutaneous routes. When heated to
decomposition it emits toxic fumes of NOx. | | References | Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971) |
| | N,N-DIETHYLNICOTINAMIDE Preparation Products And Raw materials |
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