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| | protostephanine Basic information |
| Product Name: | protostephanine | | Synonyms: | protostephanine;6,7,8,9-Tetrahydro-2,3,10,12-tetramethoxy-7-methyl-5H-dibenz[d,f]azonine;5H-Dibenz[d,f]azonine, 6,7,8,9-tetrahydro-2,3,10,12-tetramethoxy-7-methyl- | | CAS: | 549-28-0 | | MF: | C21H27NO4 | | MW: | 357.44 | | EINECS: | | | Product Categories: | | | Mol File: | 549-28-0.mol |  |
| | protostephanine Chemical Properties |
| Melting point | 84-86° (Pecherer); mp 75° (Kondo) | | Boiling point | 518.5±50.0 °C(Predicted) | | density | 1.095±0.06 g/cm3(Predicted) | | pka | 8.75±0.20(Predicted) |
| | protostephanine Usage And Synthesis |
| Description | A Stephania alkaloid, this base is found in S. japonica Miers. It forms colourless
prisms from MeOH which contain solvent of crystallization, m.p. 75°C. The
solvent may be removed under vacuum when the dry alkaloid has a higher
melting point of 90-S°C. It is optically inactive and yields crystalline saits, e.g.
the hydrochloride, m.p. 150°C (dec.); platinichloride, orange prisms, m.p. 223°C
(dec.); methiodide, m.p. 220-loC and the methomethylsulphate, m.p. 235°C
after sintering at 227°C. The structure has recently been confirmed by a synthesis
which follows a route related to the biosynthetic pathway. | | References | Kondo, Watanabe., J. Pharrn. Soc., Japan, 58,46 (1938)
Kondo, Takeda., Chern. Abstr., 49, 1076 (1955)
Synthesis:
Battersby et al., Chern. Cornrnun., 20, 1214 (1968) |
| | protostephanine Preparation Products And Raw materials |
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