| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Abacavir Carboxylate
CAS:384380-52-3
Package:10Mg,1Mg
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| | Abacavir Carboxylate Basic information |
| Product Name: | Abacavir Carboxylate | | Synonyms: | Abacavir Carboxylate;(1S,4R)-4-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]-2-cyclopentene-1-carboxylic Acid;2269W;(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-ene-1-carboxylic acid;(1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-enecarboxylic acid;2-Cyclopentene-1-carboxylic acid, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1S,4R)-;Abacavir Impurity 14 | | CAS: | 384380-52-3 | | MF: | C14H16N6O2 | | MW: | 300.32 | | EINECS: | | | Product Categories: | Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;Bases & Related Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Nucleotides;Pharmaceuticals | | Mol File: | 384380-52-3.mol |  |
| | Abacavir Carboxylate Chemical Properties |
| Melting point | 208-210°C (dec.) | | storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly, Heated, Sonicated) | | form | Solid | | color | Off-White to Pale Beige | | Stability: | Hygroscopic |
| | Abacavir Carboxylate Usage And Synthesis |
| Description | Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues. | | Chemical Properties | Off-White Solid | | Uses | Abacavir Carboxylate (Abacavir - In House Impurity) is a major metabolite of Abacavir (A105000) in human urine and cerebrospinal fluid (1,2,3). | | Definition | ChEBI: Abacavir 5'-carboxylic acid is a monocarboxylic acid oxidation product of abacavir, in which the C-5' hydroxymethyl group has been oxidised to a carboxy group. One of the two major metabolites of abacavir in humans (the other is the 5'-glucuronide, CHEBI:64189). It has a role as a metabolite. It is functionally related to an abacavir. |
| | Abacavir Carboxylate Preparation Products And Raw materials |
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