Company Name: |
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
Products Intro: |
Product Name:β-Pyrazofurin CAS:30868-30-5 Package:100Mg,10Mg
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| Pyrazofurin Basic information |
| Pyrazofurin Chemical Properties |
Boiling point | 584.4±50.0 °C(Predicted) | density | 1.785±0.06 g/cm3(Predicted) | storage temp. | -20°C | solubility | DMSO, Water (Slightly) | pka | 7.17±0.50(Predicted) | form | powder | color | white to light brown | optical activity | [α]/D -49 to -39°, c = 0.5 in H2O | Stability: | Hygroscopic |
| Pyrazofurin Usage And Synthesis |
Uses | Geldanamycin (G304500) derivative. | Definition | ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group. | Biochem/physiol Actions | Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection. | Enzyme inhibitor | This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase. |
| Pyrazofurin Preparation Products And Raw materials |
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