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| | 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Basic information |
| Product Name: | 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE | | Synonyms: | 2-(n-heptyl)-4-hydroxyquinolinen-oxide;2-heptyl-4-quinolino1-oxide;kf8940;2-Heptylquinolin-4-ol 1-oxide;Antibiotic KF-8940;Pyo II;C04284;NZPACTGCRWDXCJ-UHFFFAOYSA-N | | CAS: | 341-88-8 | | MF: | C16H21NO2 | | MW: | 259.34 | | EINECS: | | | Product Categories: | | | Mol File: | 341-88-8.mol |  |
| | 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Chemical Properties |
| Melting point | 156-157° | | Boiling point | 445.8±37.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming). | | pka | 1.07±0.40(Predicted) | | form | White to off-white crystalline solid. | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| RTECS | VC5890000 | | Toxicity | LD50 intraperitoneal in mouse: 40mg/kg |
| | 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Usage And Synthesis |
| Description | HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR). | | Uses | HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin. | | Definition | ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide. | | References | References/Citations
1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064 |
| | 2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE Preparation Products And Raw materials |
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