- Fidarestat
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- $1.00 / 1KG
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2020-01-05
- CAS: 136087-85-9
- Min. Order: 1KG
- Purity: 95--99%
- Supply Ability: 1ton
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| | Fidarestat Basic information |
| Product Name: | Fidarestat | | Synonyms: | (2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;fidarestat;(2S,4S)-6-FLUORO-2'',5''-DIOXOSPIRO(3,4-DIHYDRO-2H-1-BENZOPYRAN-4,4''-IMIDAZOLIDINE)-2-CARBOXAMIDE;(2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;SNK-860;Aldos | | CAS: | 136087-85-9 | | MF: | C12H10FN3O4 | | MW: | 279.22 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 136087-85-9.mol |  |
| | Fidarestat Chemical Properties |
| density | 1.61±0.1 g/cm3(Predicted) | | solubility | DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 8.46±0.40(Predicted) |
| | Fidarestat Usage And Synthesis |
| Biological Activity | Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes. | | in vitro | Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. | | in vivo | Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. | | target | IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10) |
| | Fidarestat Preparation Products And Raw materials |
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