| Company Name: |
Hefei fuya biotechnology co. LTD
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| Tel: |
18096409024 |
| Email: |
sales02@foreversyn.com |
| Products Intro: |
Product Name:Zetidoline
CAS:51940-78-4
Purity:95% HPLC Package:1G;100G
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| | Zetidoline Basic information |
| Product Name: | Zetidoline | | Synonyms: | Zetidoline;1-(3-Chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-yl)ethyl]-2-imidazolidinone;MDL-308;2-Imidazolidinone, 1-(3-chlorophenyl)-3-[2-(3,3-dimethyl-1-azetidinyl)ethyl]- | | CAS: | 51940-78-4 | | MF: | C16H22ClN3O | | MW: | 307.823 | | EINECS: | | | Product Categories: | | | Mol File: | 51940-78-4.mol |  |
| | Zetidoline Chemical Properties |
| | Zetidoline Usage And Synthesis |
| Originator | MDL 308 ,Dow Chemical | | Manufacturing Process | A solution of 5.0 g of 1-(m-chlorophenyl)-2-imidazolidinone in 30 ml of
dimethylformamide is added at room temperature to a mixture of 1.5 g of
50% NaH (mineral oil emulsion) in 30 ml of dimethylformamide. The reaction
mixture is stirred for 1 h at room temperature and then 4.5 g of 3,3-dimethyl-
1-(2-chloroethyl)azetidine are added. The mixture is stirred again at room
temperature for 2 h and then it is heated for 5 h at 80°-85°C. The salts are
filtered off and the solvent is removed under vacuum. The residue is taken up
with 8 ml of 18% HCl and 16 ml of water and extracted with diethyl ether.
The water solution is alkalinized by addition of 15% sodium carbonate and
then extracted with diethyl ether. By evaporation of the organic layer a
residue is obtained that is triturated in light petroleum. Yield of 1-(m-
chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-y1)ethyl]-2-imidazolidinone 7.25
g, melting point 84°-85°C (after recrystallization from hexane). | | Therapeutic Function | Antipsychotic, Neuroleptic |
| | Zetidoline Preparation Products And Raw materials |
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